Polymorphic Forms of Lamivudine : Characterization, Estimation of Transition Temperature, and Stability Studies by Thermodynamic and Spectroscopic Studies
المؤلفون المشاركون
Chadha, Renu
Arora, Poonam
Bhandari, Swati
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The present study is focused on estimation of transition temperature and stability of various forms of lamivudine.
The forms were recrystallized from variety of solvents and preliminarily identification on the basis of SEM revealed existence of three forms (Forms I, II, III).
DSC scans of Forms I and III show that these are metastable and undergo heat mediated transformation to Form IH and Form IIIH, respectively.
Form II is phase pure with single sharp melting endotherm at 178.6°C.
The thermal events are visually observed by hot stage microscopy.
Enthalpy of solution of the forms is endothermic and magnitude varies in the order Form II > Form IL > Form IIIL suggesting Form IIIL to be least crystalline which is well correlated with XRPD data.
The transition temperature of the polymorphic pairs IL/IH and IIIL/IIIH derived from enthalpy of solution and solubility data revealed monotropy whereas enantiotropy exists in IIIH/II.
The slurry experiments showed Form II to be thermodynamically most stable.
Forms IL and IIIL though stable in water are converted to Form II in ethanol, acetonitrile, and propanol after 1 day.
Form IIIL is converted to Form IL in water after 7 days and the observation is of importance as this instability can effect the pharmaceutical preparations whereas Form IL shows a balance between stability and solubility.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chadha, Renu& Arora, Poonam& Bhandari, Swati. 2012. Polymorphic Forms of Lamivudine : Characterization, Estimation of Transition Temperature, and Stability Studies by Thermodynamic and Spectroscopic Studies. ISRN Thermodynamics،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-489162
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chadha, Renu…[et al.]. Polymorphic Forms of Lamivudine : Characterization, Estimation of Transition Temperature, and Stability Studies by Thermodynamic and Spectroscopic Studies. ISRN Thermodynamics No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-489162
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chadha, Renu& Arora, Poonam& Bhandari, Swati. Polymorphic Forms of Lamivudine : Characterization, Estimation of Transition Temperature, and Stability Studies by Thermodynamic and Spectroscopic Studies. ISRN Thermodynamics. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-489162
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489162
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر