Characterization of the Duffy-Binding-Like Domain of Plasmodium falciparum Blood-Stage Antigen 332

المؤلفون المشاركون

Berzins, Klavs
Kursula, Inari
Albrecht, Letusa
Chen, Qijun
Jiang, Ning
Angeletti, Davide
Wahlgren, Mats
Moll, Kirsten
Nilsson, Sandra
Sun, Xiaodong

المصدر

Malaria Research and Treatment

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-09-19

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Studies on Pf332, a major Plasmodium falciparum blood-stage antigen, have largely been hampered by the cross-reactive nature of antibodies generated against the molecule due to its high content of repeats, which are present in other malaria antigens.

We previously reported the identification of a conserved domain in Pf332 with a high degree of similarity to the Duffy-binding-like (DBL) domains of the erythrocyte-binding-like (EBL) family.

We here describe that antibodies towards Pf332-DBL are induced after repeated exposure to P.

falciparum and that they are acquired early in life in areas of intense malaria transmission.

Furthermore, a homology model of Pf332-DBL was found to be similar to the structure of the EBL-DBLs.

Despite their similarities, antibodies towards Pf332-DBL did not display any cross-reactivity with EBL-proteins as demonstrated by immunofluorescence microscopy, Western blotting, and peptide microarray.

Thus the DBL domain is an attractive region to use in further studies on the giant Pf332 molecule.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Nilsson, Sandra& Moll, Kirsten& Angeletti, Davide& Albrecht, Letusa& Kursula, Inari& Jiang, Ning…[et al.]. 2011. Characterization of the Duffy-Binding-Like Domain of Plasmodium falciparum Blood-Stage Antigen 332. Malaria Research and Treatment،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-489202

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Nilsson, Sandra…[et al.]. Characterization of the Duffy-Binding-Like Domain of Plasmodium falciparum Blood-Stage Antigen 332. Malaria Research and Treatment No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-489202

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Nilsson, Sandra& Moll, Kirsten& Angeletti, Davide& Albrecht, Letusa& Kursula, Inari& Jiang, Ning…[et al.]. Characterization of the Duffy-Binding-Like Domain of Plasmodium falciparum Blood-Stage Antigen 332. Malaria Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-489202

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-489202