Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism

المؤلفون المشاركون

Mamtani, Manju
Badhoniya, Neetu
Dibley, Michael J.
Patel, Archana B.
Kulkarni, Hemant

المصدر

International Journal of Pediatrics

العدد

المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-05-31

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Zinc supplementation is recommended in all acute diarrheas in children from developing countries.

We aimed to assess whether zinc supplementation would be equally effective against all the common organisms associated with acute diarrheas.

We used data on 801 children with acute diarrhea recruited in a randomized, double blind controlled trial (ISRCTN85071383) of zinc and copper supplementation.

Using prespecified subgroup analyses, multidimensionality reduction analyses, tests of heterogeneity, and stepwise logistic regression for tests of interactions, we found that the influence of zinc on the risk of diarrhea for more than 3 days depended on the isolated organism—beneficial in Klebsiella, neutral in Esherichia coli and parasitic infections, and detrimental in rotavirus coinfections.

Although we found similar results for the outcome of high stool volume, the results did not reach statistical significance.

Our findings suggest that the current strategy of zinc supplementation in all cases of acute diarrheas in children may need appropriate fine tuning to optimize the therapeutic benefit based on the causative organism, but further studies need to confirm and extend our findings.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Patel, Archana B.& Dibley, Michael J.& Mamtani, Manju& Badhoniya, Neetu& Kulkarni, Hemant. 2010. Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism. International Journal of Pediatrics،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-489213

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Patel, Archana B.…[et al.]. Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism. International Journal of Pediatrics No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-489213

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Patel, Archana B.& Dibley, Michael J.& Mamtani, Manju& Badhoniya, Neetu& Kulkarni, Hemant. Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism. International Journal of Pediatrics. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-489213

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-489213