Safety Evaluation of Yukmijihwang-tang : Assessment of Acute and Subchronic Toxicity in Rats
المؤلفون المشاركون
Shin, Hyeun-Kyoo
Seo, Chang-Seob
Huang, Dae Sun
Lee, Mi-Young
Ha, Hyekyung
Lee, Jun Kyoung
Koh, Woo Suk
Lee, Ho Young
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-12-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Yukmijihwang-tang (YMJ; Liu wei di huang tang (China), Rokumigan (Japan)) has been used in the treatment of diseases including renal disorder, cognitive vitality, and diabetes mellitus.
However, there is very little information regarding the toxicity of YMJ to give an assurance of safety for clinical treatment.
To provide safety information for YMJ, we evaluated its acute and sub-chronic toxicity in rats.
The single-dose toxicity of YMJ was examined using Sprague-Dawley rats.
Rats were treated with YMJ extract orally at 0, 500, 1000, or 2000 mg/kg body weight.
After a single administration, clinical signs were observed every day for two weeks, and body weights were measured five times, including an initial measurement on day 1 (the day of administration).
In the sub-chronic oral toxicity study, YMJ was administered to rats at 0, 500, 1000, or 2000 mg/kg/day for 13 weeks.
Mortalities, clinical signs, body weight changes, food and water consumption, ophthalmologic findings, urinalysis, hematological and biochemical parameters, gross findings, organ weights, and histological examination were monitored during the study period.
We found no mortality and no abnormalities in clinical signs, body weights, and necropsy findings for any of the animals in the acute and sub-chronic studies following oral administration in the rat at up to 2000 mg/kg/day YMJ.
YMJ may not have any single-dose toxicity; the LD50 of YMJ was over 2000 mg/kg, and it is safe for rats.
The no-observed-adverse-effect-level (NOAEL) was considered to be 2000 mg/kg/day.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ha, Hyekyung& Lee, Jun Kyoung& Lee, Ho Young& Koh, Woo Suk& Seo, Chang-Seob& Lee, Mi-Young…[et al.]. 2010. Safety Evaluation of Yukmijihwang-tang : Assessment of Acute and Subchronic Toxicity in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-489263
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ha, Hyekyung…[et al.]. Safety Evaluation of Yukmijihwang-tang : Assessment of Acute and Subchronic Toxicity in Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-489263
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ha, Hyekyung& Lee, Jun Kyoung& Lee, Ho Young& Koh, Woo Suk& Seo, Chang-Seob& Lee, Mi-Young…[et al.]. Safety Evaluation of Yukmijihwang-tang : Assessment of Acute and Subchronic Toxicity in Rats. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-489263
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489263
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر