The Effect of Glucagon-Like Peptide-2 Receptor Agonists on Colonic Anastomotic Wound Healing
المؤلفون المشاركون
Sigalet, David L.
Redstone, Heather A.
Buie, William D.
Holst, Jens Juul
Hart, David A.
Hornby, Pamela J.
Wallace, Laurie
Sague, Sarah
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-10-04
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Glucagon-like peptide 2 (GLP-2) is an intestinal specific trophic hormone, with therapeutic potential; the effects on intestinal healing are unknown.
We used a rat model of colonic healing, under normoxic, and stress (hypoxic) conditions to examine the effect of GLP-2 on intestinal healing.
Methods.
Following colonic transection and reanastomosis, animals were randomized to one of six groups (n=8/group): controls, native GLP-2, long-acting GLP-2 (GLP-2- MIMETIBODY, GLP-2-MMB), animals were housed under normoxic or hypoxic (11% O2) conditions.
Animals were studied five days post-operation for anastomotic strength and wound characteristics.
Results.
Anastomotic bursting pressure was unchanged by GLP-2 or GLP-2-MMB in normoxic or hypoxic animals; both treatments increased crypt cell proliferation.
Wound IL-1β increased with GLP-2; IFNγ with GLP-2 and GLP-2-MMB.
IL-10 and TGF-β were decreased; Type I collagen mRNA expression increased in hypoxic animals while Type III collagen was reduced with both GLP-2 agonists.
GLP-2 MMB, but not native GLP-2 increased TIMP 1-3 mRNA levels in hypoxia.
Conclusions.
The effects on CCP, cytokines and wound healing were similar for both GLP-2 agonists under normoxic and hypoxic conditions; anastomotic strength was not affected.
This suggests that GLP-2 (or agonists) could be safely used peri-operatively; direct studies will be required.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Redstone, Heather A.& Buie, William D.& Hart, David A.& Wallace, Laurie& Hornby, Pamela J.& Sague, Sarah…[et al.]. 2010. The Effect of Glucagon-Like Peptide-2 Receptor Agonists on Colonic Anastomotic Wound Healing. Gastroenterology Research and Practice،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-489290
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Redstone, Heather A.…[et al.]. The Effect of Glucagon-Like Peptide-2 Receptor Agonists on Colonic Anastomotic Wound Healing. Gastroenterology Research and Practice No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-489290
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Redstone, Heather A.& Buie, William D.& Hart, David A.& Wallace, Laurie& Hornby, Pamela J.& Sague, Sarah…[et al.]. The Effect of Glucagon-Like Peptide-2 Receptor Agonists on Colonic Anastomotic Wound Healing. Gastroenterology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-489290
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489290
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر