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Structure-Function Correlation Analysis of Connexin50 Missense Mutations Causing Congenital Cataract : Electrostatic Potential Alteration Could Determine Intracellular Trafficking Fate of Mutants
المؤلفون المشاركون
Ray, Kunal
Sengupta, Mainak
Sarkar, Devroop
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-06
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Connexin50 (Cx50) mutations are reported to cause congenital cataract probably through the disruption of intercellular transport in the lens.
Cx50 mutants that undergo mistrafficking have generally been associated with failure to form functional gap junction channels; however, sometimes even properly trafficked mutants were found to undergo similar consequences.
We hereby wanted to elucidate any structural bases of the varied functional consequences of Cx50 missense mutations through in silico approach.
Computational studies have been done based on a Cx50 homology model to assess conservation, solvent accessibility, and 3-dimensional localization of mutated residues as well as mutation-induced changes in surface electrostatic potential, H-bonding, and steric clash.
This was supplemented with meta-analysis of published literature on the functional properties of connexin missense mutations.
Analyses revealed that the mutation-induced critical alterations of surface electrostatic potential in Cx50 mutants could determine their fate in intracellular trafficking.
A similar pattern was observed in case of mutations involving corresponding conserved residues in other connexins also.
Based on these results the trafficking fates of 10 uncharacterized Cx50 mutations have been predicted.
Further experimental analyses are needed to validate the observed correlation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sarkar, Devroop& Ray, Kunal& Sengupta, Mainak. 2014. Structure-Function Correlation Analysis of Connexin50 Missense Mutations Causing Congenital Cataract : Electrostatic Potential Alteration Could Determine Intracellular Trafficking Fate of Mutants. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-489441
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sarkar, Devroop…[et al.]. Structure-Function Correlation Analysis of Connexin50 Missense Mutations Causing Congenital Cataract : Electrostatic Potential Alteration Could Determine Intracellular Trafficking Fate of Mutants. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-489441
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sarkar, Devroop& Ray, Kunal& Sengupta, Mainak. Structure-Function Correlation Analysis of Connexin50 Missense Mutations Causing Congenital Cataract : Electrostatic Potential Alteration Could Determine Intracellular Trafficking Fate of Mutants. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-489441
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489441
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