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Ankylosing Spondylitis and Rheumatoid Arthritis : Serum Levels of TNF-α and Its Soluble Receptors during the Course of Therapy with Etanercept and Infliximab
المؤلفون المشاركون
Neeck, Gunther
Dotzlaw, Helmut
Schulz, Martin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The effects of the TNF-α blockers infliximab or etanercept on the levels of TNF-α, TNF-receptor 1 (TNF-R1), and TNF-receptor 2 (TNF-R2), as well as the levels of the inflammation markers CRP and IL-6, were measured in ankylosing spondylitis (AS) and rheumatoid arthritis (RA) patients receiving treatment with either compound.
We found that RA patients tend to have higher levels of TNF-α than both healthy individuals and AS patients prior to treatment (P<0.05).
We measured greatly increased levels of TNF-α in both the AS and RA etanercept patient groups during the course of treatment, while in the infliximab treated patients, the amount of TNF-α measured remained unchanged.
Elevated TNF-α in the etanercept treated patients does not appear to be a significant risk factor for the spontaneous development of further autoimmune diseases in our study group.
Increased levels of TNF-R1 were determined in both AS (P<0.05) and RA (P<0.001) patients when compared to healthy controls.
In AS patients, the levels of TNF-R1 dropped significantly when treated with either infliximab (P<0.01) or etanercept (P<0.001).
In contrast, the levels of this receptor remained unchanged in RA patients treated with either compound.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schulz, Martin& Dotzlaw, Helmut& Neeck, Gunther. 2014. Ankylosing Spondylitis and Rheumatoid Arthritis : Serum Levels of TNF-α and Its Soluble Receptors during the Course of Therapy with Etanercept and Infliximab. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-489561
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schulz, Martin…[et al.]. Ankylosing Spondylitis and Rheumatoid Arthritis : Serum Levels of TNF-α and Its Soluble Receptors during the Course of Therapy with Etanercept and Infliximab. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-489561
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schulz, Martin& Dotzlaw, Helmut& Neeck, Gunther. Ankylosing Spondylitis and Rheumatoid Arthritis : Serum Levels of TNF-α and Its Soluble Receptors during the Course of Therapy with Etanercept and Infliximab. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-489561
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489561
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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