Monocolonization of Germ-Free Mice with Bacteroides fragilis Protects against Dextran Sulfate Sodium-Induced Acute Colitis
المؤلفون المشاركون
Huang, Yen-Te
Li, Yen-Peng
Wang, Yu-Chih
Chuang, Hsiao-Li
Liu, Ju-Yun
Chiu, Chien-Chao
Ching, Yung-Hao
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Ulcerative colitis is inflammatory conditions of the colon caused by interplay of genetic and environmental factors.
Previous studies indicated that the gut microflora may be involved in the colonic inflammation.
Bacteroides fragilis (BF) is a Gram-negative anaerobe belonging to the colonic symbiotic.
We aimed to investigate the protective role of BF in a colitis model induced in germ-free (GF) mice by dextran sulfate sodium (DSS).
GF C57BL/6JNarl mice were colonized with BF for 28 days before acute colitis was induced by DSS.
BF colonization significantly increased animal survival by 40%, with less reduction in colon length, and decreased infiltration of inflammatory cells (macrophages and neutrophils) in colon mucosa following challenge with DSS.
In addition, BF could enhance the mRNA expression of anti-inflammatory-related cytokine such as interleukin 10 (IL-10) with polymorphism cytokine IL-17 and diminish that of proinflammatory-related tumor necrosis factor α with inducible nitric oxide synthase in the ulcerated colon.
Myeloperoxidase activity was also decreased in BF-DSS mice.
Taking these together, the BF colonization significantly ameliorated DSS-induced colitis by suppressing the activity of inflammatory-related molecules and inducing the production of anti-inflammatory cytokines.
BF may play an important role in maintaining intestinal immune system homeostasis and regulate inflammatory responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chiu, Chien-Chao& Ching, Yung-Hao& Wang, Yu-Chih& Liu, Ju-Yun& Li, Yen-Peng& Huang, Yen-Te…[et al.]. 2014. Monocolonization of Germ-Free Mice with Bacteroides fragilis Protects against Dextran Sulfate Sodium-Induced Acute Colitis. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-489616
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chiu, Chien-Chao…[et al.]. Monocolonization of Germ-Free Mice with Bacteroides fragilis Protects against Dextran Sulfate Sodium-Induced Acute Colitis. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-489616
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chiu, Chien-Chao& Ching, Yung-Hao& Wang, Yu-Chih& Liu, Ju-Yun& Li, Yen-Peng& Huang, Yen-Te…[et al.]. Monocolonization of Germ-Free Mice with Bacteroides fragilis Protects against Dextran Sulfate Sodium-Induced Acute Colitis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-489616
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489616
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر