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Atherogenesis May Involve the Prooxidant and Proinflammatory Effects of Ferryl Hemoglobin
المؤلفون المشاركون
Becs, Gergely
Balla, József
Balla, György
Jeney, Viktória
Soares, Miguel P.
Bányai, Emese
Potor, László
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-15
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Oxidized cell-free hemoglobin (Hb), including covalently cross-linked Hb multimers, is present in advanced atherosclerotic lesions.
Oxidation of Hb produces methemoglobin (Fe3+) and ferryl hemoglobin (Fe4+=O2−).
Ferryl iron is unstable and can return to the Fe3+ state by reacting with specific amino acids of the globin chains.
In these reactions globin radicals are produced followed by termination reactions yielding covalently cross-linked Hb multimers.
Despite the evanescent nature of the ferryl state, herein we refer to this oxidized Hb as “ferryl Hb.” Our aim in this work was to study formation and biological effects of ferrylHb.
We demonstrate that ferrylHb, like metHb, can release its heme group, leading to sensitization of endothelial cells (ECs) to oxidant-mediated killing and to oxidation of low-density lipoprotein (LDL).
Furthermore, we observed that both oxidized LDL and lipids derived from human atherosclerotic lesions trigger Hb oxidation and subsequent production of covalently cross-linked ferrylHb multimers.
Previously we showed that ferrylHb disrupts EC monolayer integrity and induces expression of inflammatory cell adhesion molecules.
Here we show that when exposed to ferrylHb, EC monolayers exhibit increased permeability and enhanced monocyte adhesion.
Taken together, interactions between cell-free Hb and atheroma lipids engage in a vicious cycle, amplifying oxidation of plaque lipids and Hb.
These processes trigger EC activation and cytotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Potor, László& Bányai, Emese& Becs, Gergely& Soares, Miguel P.& Balla, György& Balla, József…[et al.]. 2013. Atherogenesis May Involve the Prooxidant and Proinflammatory Effects of Ferryl Hemoglobin. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-489674
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Potor, László…[et al.]. Atherogenesis May Involve the Prooxidant and Proinflammatory Effects of Ferryl Hemoglobin. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-489674
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Potor, László& Bányai, Emese& Becs, Gergely& Soares, Miguel P.& Balla, György& Balla, József…[et al.]. Atherogenesis May Involve the Prooxidant and Proinflammatory Effects of Ferryl Hemoglobin. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-489674
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489674
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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