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Multiple Regression Analysis of mRNA-miRNA Associations in Colorectal Cancer Pathway
المؤلفون المشاركون
Wong, S. C. Cesar
Chan, Lawrence W. C.
Wang, Fengfeng
Yung, Benjamin Y. M.
Cho, William Chi-Shing
Yip, Shea Ping
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
MicroRNA (miRNA) is a short and endogenous RNA molecule that regulates posttranscriptional gene expression.
It is an important factor for tumorigenesis of colorectal cancer (CRC), and a potential biomarker for diagnosis, prognosis, and therapy of CRC.
Our objective is to identify the related miRNAs and their associations with genes frequently involved in CRC microsatellite instability (MSI) and chromosomal instability (CIN) signaling pathways.
Results.
A regression model was adopted to identify the significantly associated miRNAs targeting a set of candidate genes frequently involved in colorectal cancer MSI and CIN pathways.
Multiple linear regression analysis was used to construct the model and find the significant mRNA-miRNA associations.
We identified three significantly associated mRNA-miRNA pairs: BCL2 was positively associated with miR-16 and SMAD4 was positively associated with miR-567 in the CRC tissue, while MSH6 was positively associated with miR-142-5p in the normal tissue.
As for the whole model, BCL2 and SMAD4 models were not significant, and MSH6 model was significant.
The significant associations were different in the normal and the CRC tissues.
Conclusion.
Our results have laid down a solid foundation in exploration of novel CRC mechanisms, and identification of miRNA roles as oncomirs or tumor suppressor mirs in CRC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Fengfeng& Wong, S. C. Cesar& Chan, Lawrence W. C.& Cho, William Chi-Shing& Yip, Shea Ping& Yung, Benjamin Y. M.. 2014. Multiple Regression Analysis of mRNA-miRNA Associations in Colorectal Cancer Pathway. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-489691
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Fengfeng…[et al.]. Multiple Regression Analysis of mRNA-miRNA Associations in Colorectal Cancer Pathway. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-489691
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Fengfeng& Wong, S. C. Cesar& Chan, Lawrence W. C.& Cho, William Chi-Shing& Yip, Shea Ping& Yung, Benjamin Y. M.. Multiple Regression Analysis of mRNA-miRNA Associations in Colorectal Cancer Pathway. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-489691
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489691
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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