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Mannan-Binding Lectin in Diabetic Kidney Disease : The Impact of Mouse Genetics in a Type 1 Diabetes Model
المؤلفون المشاركون
Bjerre, Mette
Sharma, Kumar
Thiel, Steffen
Flyvbjerg, Allan
Hansen, Troels Krarup
Nyengaard, Jens Randel
Østergaard, Jakob Appel
RamachandraRao, Satish Posettihalli
المصدر
Experimental Diabetes Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Mannan-binding lectin (MBL) is involved in the development of diabetic nephropathy.
MBL is a part of the innate immune system where it can activate the complement system.
Serum MBL level predicts later renal impairment in diabetes patients.
Direct involvement of MBL in the development of diabetic kidney disease is observed in one animal strain.
However, this involvement may differ among the animal strains.
We thus examined the impact of the genetic background on the role of MBL in diabetic nephropathy.
Materials/Methods.
C57BL/6JBomTac and 129S6/SvEvTac mice were compared.
In both strains, experimental type 1 diabetes was induced in wild-type (WT) and MBL-knockout (MBL-KO) mice by streptozotocin.
Nondiabetic WT and MBL-KO mice were used as controls.
We tested if MBL modified the diabetes-induced kidney changes by two-way ANOVA allowing for interaction.
Results.
MBL aggravated diabetes-induced kidney growth and glomerulus enlargement in C57BL/6JBomTac mice.
MBL did not modify diabetes effects on glomerular basement membrane thickness or mesangial volume in any strain.
Diabetes-induced changes in renal gene transcription of growth factors and matrix components were unaffected by MBL.
Conclusions.
Strain-specific MBL effects were found on downstream diabetic kidney changes.
This emphasizes the importance of genetic background in this model of diabetic complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Østergaard, Jakob Appel& Bjerre, Mette& RamachandraRao, Satish Posettihalli& Sharma, Kumar& Nyengaard, Jens Randel& Hansen, Troels Krarup…[et al.]. 2012. Mannan-Binding Lectin in Diabetic Kidney Disease : The Impact of Mouse Genetics in a Type 1 Diabetes Model. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-489765
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Østergaard, Jakob Appel…[et al.]. Mannan-Binding Lectin in Diabetic Kidney Disease : The Impact of Mouse Genetics in a Type 1 Diabetes Model. Experimental Diabetes Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-489765
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Østergaard, Jakob Appel& Bjerre, Mette& RamachandraRao, Satish Posettihalli& Sharma, Kumar& Nyengaard, Jens Randel& Hansen, Troels Krarup…[et al.]. Mannan-Binding Lectin in Diabetic Kidney Disease : The Impact of Mouse Genetics in a Type 1 Diabetes Model. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-489765
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489765
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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