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Effects of Acupuncture on CCL2 and CXCL8 Expression and the Subset of uNK Cells in Rats with Embryo Implantation Failure
المؤلفون المشاركون
Tang, Xiao
Zhang, Mingmin
Huang, Guangying
Guo, Yue
Gao, Weina
Wang, Lijun
Chen, Zhenyan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-15
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The present study was designed to investigate the efficacy and mechanism of acupuncture treatment on embryo implantation failure in rats.
The pregnant rats were randomized into normal group (N), implantation failure group (M), acupuncture treatment group (A), and progestin treatment group (W).
The embryo implantation failure model was established by mifepristone.
Efficacy of acupuncture treatment was evaluated by the number of implanted embryos.
The expression of CCL2 and CXCL8 and the subset of uterine natural killer cells in the endometrium were detected.
We demonstrated that the number of implanted embryos was dramatically reduced after mifepristone (M group) treatment, while the acupuncture (A group) and progestin (W group) treatments significantly rescued impaired embryo implantation.
The protein and mRNA expressions of CCL2 and CXCL8 were significantly reduced by mifepristone treatment, but the attenuated expression of CCL2 and CXCL8 was markedly reversed by acupuncture or progestin treatment.
More importantly, acupuncture and progestin could markedly increase the subset of uNK cells in rats with embryo implantation failure.
These evidences suggest that acupuncture is able to modulate the endometrial immune microenvironment and thus improve embryo implantation in pregnant rats, which provides solid experimental evidence for the curative effect of acupuncture treatment on infertility.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gao, Weina& Tang, Xiao& Chen, Zhenyan& Guo, Yue& Wang, Lijun& Zhang, Mingmin…[et al.]. 2013. Effects of Acupuncture on CCL2 and CXCL8 Expression and the Subset of uNK Cells in Rats with Embryo Implantation Failure. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-489766
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gao, Weina…[et al.]. Effects of Acupuncture on CCL2 and CXCL8 Expression and the Subset of uNK Cells in Rats with Embryo Implantation Failure. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-489766
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gao, Weina& Tang, Xiao& Chen, Zhenyan& Guo, Yue& Wang, Lijun& Zhang, Mingmin…[et al.]. Effects of Acupuncture on CCL2 and CXCL8 Expression and the Subset of uNK Cells in Rats with Embryo Implantation Failure. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-489766
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489766
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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