Modulation of Cell Death by M. tuberculosis as a Strategy for Pathogen Survival
المؤلفون المشاركون
Kim, Louise
Engers, Howard
Wassie, Liya
Rook, Graham
Abebe, Markos
Zumla, Alimuddin
Aseffa, Abraham
Andersen, Peter L.
Doherty, T. Mark
Zewdie, Martha
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-01-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
It has been clearly demonstrated that in vitro, virulent M.
tuberculosis can favor necrosis over apoptosis in infected macrophages, and this has been suggested as a mechanism for evading the host immune response.
We recently reported that an effect consistent with this hypothesis could be observed in cells from the blood of TB patients, and in this paper, we review what is known about evasion strategies employed by M.
tuberculosis and in particular consider the possible interaction of the apoptosis-inhibiting effects of M.
tuberculosis infection with another factor (IL-4) whose expression is thought to play a role in the failure to control M.
tuberculosis infection.
It has been noted that IL-4 may exacerbate TNF-α-induced pathology, though the mechanism remains unexplained.
Since pathology in TB typically involves inflammatory aggregates around infected cells, where TNF-α plays an important role, we predicted that IL-4 would inhibit the ability of cells to remove M.
tuberculosis by apoptosis of infected cells, through the extrinsic pathway, which is activated by TNF-α.
Infection of human monocytic cells with mycobacteria in vitro, in the presence of IL-4, appears to promote necrosis over apoptosis in infected cells—a finding consistent with its suggested role as a factor in pathology during M.
tuberculosis infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abebe, Markos& Kim, Louise& Rook, Graham& Aseffa, Abraham& Wassie, Liya& Zewdie, Martha…[et al.]. 2011. Modulation of Cell Death by M. tuberculosis as a Strategy for Pathogen Survival. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-489784
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abebe, Markos…[et al.]. Modulation of Cell Death by M. tuberculosis as a Strategy for Pathogen Survival. Clinical and Developmental Immunology No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-489784
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abebe, Markos& Kim, Louise& Rook, Graham& Aseffa, Abraham& Wassie, Liya& Zewdie, Martha…[et al.]. Modulation of Cell Death by M. tuberculosis as a Strategy for Pathogen Survival. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-489784
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489784
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر