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Artesunate Exerts a Direct Effect on Endothelial Cell Activation and NF-κB Translocation in a Mechanism Independent of Plasmodium Killing
المؤلفون المشاركون
Ribeiro, Isabela
Paixão, Flávio Henrique Marcolino
Souza, Mariana C.
Henriques, Maria das Graças M. O.
Ferraris, Fausto K.
المصدر
Malaria Research and Treatment
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-11
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Artemisinin and its derivates are an important class of antimalarial drug and are described to possess immunomodulatory activities.
Few studies have addressed the effect of artesunate in the murine malaria model or its effect on host immune response during malaria infection.
Herein, we study the effect of artesunate treatment and describe an auxiliary mechanism of artesunate in modulating the inflammatory response during experimental malaria infection in mice.
Treatment with artesunate did not reduce significantly the parasitemia within 12 h, however, reduced BBB breakdown and TNF-α mRNA expression in the brain tissue of artesunate-treated mice.
Conversely, mefloquine treatment was not able to alter clinical features.
Notably, artesunate pretreatment failed to modulate the expression of LFA-1 in splenocytes stimulated with parasitized red blood cells (pRBCs) in vitro; however, it abrogated the expression of ICAM-1 in pRBC-stimulated endothelial cells.
Accordingly, a cytoadherence in vitro assay demonstrated that pRBCs did not adhere to artesunate-treated vascular endothelial cells.
In addition, NF-κB nuclear translocation in endothelial cells stimulated with pRBCs was impaired by artesunate treatment.
Our results suggest that artesunate is able to exert a protective effect against the P.
berghei-induced inflammatory response by inhibiting NF-κB nuclear translocation and the subsequent expression of ICAM-1.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Souza, Mariana C.& Paixão, Flávio Henrique Marcolino& Ferraris, Fausto K.& Ribeiro, Isabela& Henriques, Maria das Graças M. O.. 2012. Artesunate Exerts a Direct Effect on Endothelial Cell Activation and NF-κB Translocation in a Mechanism Independent of Plasmodium Killing. Malaria Research and Treatment،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-489830
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Souza, Mariana C.…[et al.]. Artesunate Exerts a Direct Effect on Endothelial Cell Activation and NF-κB Translocation in a Mechanism Independent of Plasmodium Killing. Malaria Research and Treatment No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-489830
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Souza, Mariana C.& Paixão, Flávio Henrique Marcolino& Ferraris, Fausto K.& Ribeiro, Isabela& Henriques, Maria das Graças M. O.. Artesunate Exerts a Direct Effect on Endothelial Cell Activation and NF-κB Translocation in a Mechanism Independent of Plasmodium Killing. Malaria Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-489830
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489830
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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