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A Bayesian Framework for Functional Mapping through Joint Modeling of Longitudinal and Time-to-Event Data
المؤلفون المشاركون
Das, Kiranmoy
Gai, Junyi
Huang, Zhongwen
Li, Runze
Wu, Rongling
المصدر
International Journal of Plant Genomics
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-22
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The most powerful and comprehensive approach of study in modern biology is to understand the whole process of development and all events of importance to development which occur in the process.
As a consequence, joint modeling of developmental processes and events has become one of the most demanding tasks in statistical research.
Here, we propose a joint modeling framework for functional mapping of specific quantitative trait loci (QTLs) which controls developmental processes and the timing of development and their causal correlation over time.
The joint model contains two submodels, one for a developmental process, known as a longitudinal trait, and the other for a developmental event, known as the time to event, which are connected through a QTL mapping framework.
A nonparametric approach is used to model the mean and covariance function of the longitudinal trait while the traditional Cox proportional hazard (PH) model is used to model the event time.
The joint model is applied to map QTLs that control whole-plant vegetative biomass growth and time to first flower in soybeans.
Results show that this model should be broadly useful for detecting genes controlling physiological and pathological processes and other events of interest in biomedicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Das, Kiranmoy& Li, Runze& Huang, Zhongwen& Gai, Junyi& Wu, Rongling. 2012. A Bayesian Framework for Functional Mapping through Joint Modeling of Longitudinal and Time-to-Event Data. International Journal of Plant Genomics،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-489990
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Das, Kiranmoy…[et al.]. A Bayesian Framework for Functional Mapping through Joint Modeling of Longitudinal and Time-to-Event Data. International Journal of Plant Genomics No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-489990
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Das, Kiranmoy& Li, Runze& Huang, Zhongwen& Gai, Junyi& Wu, Rongling. A Bayesian Framework for Functional Mapping through Joint Modeling of Longitudinal and Time-to-Event Data. International Journal of Plant Genomics. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-489990
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489990
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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