Biologic Propensities and Phytochemical Profile of Vangueria madagascariensis J. F. Gmelin (Rubiaceae)‎ : An Underutilized Native Medicinal Food Plant from Africa

الملخص EN

Vangueria madagascariensis (VM), consumed for its sweet-sour fruits, is used as a biomedicine for the management of diabetes and bacterial infections in Africa.

The study aims to assess the potential of VM on α-amylase, α-glucosidase, glucose movement, and antimicrobial activity.

The antioxidant properties were determined by measuring the FRAP, iron chelating activity, and abilities to scavenge DPPH, HOCl, ∙OH, and NO radicals.

Leaf decoction, leaf methanol, and unripe fruit methanol extracts were observed to significantly inhibit α-amylase.

Active extracts against α-glucosidase were unripe fruit methanol, unripe fruit decoction, leaf decoction, and ripe fruit methanol, which were significantly lower than acarbose.

Kinetic studies revealed a mixed noncompetitive type of inhibition.

Leaf methanolic extract was active against S.

aureus and E.

coli.

Total phenolic content showed a strong significant positive correlation (r=0.88) with FRAP.

Methanolic leaf extract showed a more efficient NO scavenging potential and was significantly lower than ascorbic acid.

Concerning ∙OH-mediated DNA degradation, only the methanol extracts of leaf, unripe fruit, and ripe fruit had IC50 values which were significantly lower than α-tocopherol.

Given the dearth of information on the biologic propensities of VM, this study has established valuable primary information which has opened new perspectives for further pharmacological research.