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Role of Uropathogenic Escherichia coli Virulence Factors in Development of Urinary Tract Infection and Kidney Damage
المؤلفون المشاركون
Sokolova, Olga
Bien, Justyna
Bozko, Przemyslaw
المصدر
International Journal of Nephrology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-08
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Uropathogenic Escherichia coli (UPEC) is a causative agent in the vast majority of urinary tract infections (UTIs), including cystitis and pyelonephritis, and infectious complications, which may result in acute renal failure in healthy individuals as well as in renal transplant patients.
UPEC expresses a multitude of virulence factors to break the inertia of the mucosal barrier.
In response to the breach by UPEC into the normally sterile urinary tract, host inflammatory responses are triggered leading to cytokine production, neutrophil influx, and the exfoliation of infected bladder epithelial cells.
Several signaling pathways activated during UPEC infection, including the pathways known to activate the innate immune response, interact with calcium-dependent signaling pathways.
Some UPEC isolates, however, might possess strategies to delay or suppress the activation of components of the innate host response in the urinary tract.
Studies published in the recent past provide new information regarding how virulence factors of uropathogenic E.
coli are involved in activation of the innate host response.
Despite numerous host defense mechanisms, UPEC can persist within the urinary tract and may serve as a reservoir for recurrent infections and serious complications.
Presentation of the molecular details of these events is essential for development of successful strategies for prevention of human UTIs and urological complications associated with UTIs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bien, Justyna& Sokolova, Olga& Bozko, Przemyslaw. 2012. Role of Uropathogenic Escherichia coli Virulence Factors in Development of Urinary Tract Infection and Kidney Damage. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-490069
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bien, Justyna…[et al.]. Role of Uropathogenic Escherichia coli Virulence Factors in Development of Urinary Tract Infection and Kidney Damage. International Journal of Nephrology No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-490069
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bien, Justyna& Sokolova, Olga& Bozko, Przemyslaw. Role of Uropathogenic Escherichia coli Virulence Factors in Development of Urinary Tract Infection and Kidney Damage. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-490069
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490069
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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