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B Cells in Rheumatoid Arthritis : From Pathogenic Players to Disease Biomarkers
المؤلفون المشاركون
Caporali, Roberto
Manzo, Antonio
Vitolo, Barbara
Montecucco, Carlomaurizio
Bugatti, Serena
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-29
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The therapeutic benefit of depleting B cells in rheumatoid arthritis (RA) has refocused attention on B cells with increasing awareness on their role in autoimmunity and their function beyond autoantibody production.
The rapid increase in our comprehension of B-cell pathobiology is progressively opening novel perspectives in the area of B cell-targeted therapies with the expectation to define more specific approaches able to preserve the homeostasis of the humoral response while disrupting the pathogenic components.
In parallel, B-cell activity in RA is starting to be explored in its clinical value, in search of novel biomarkers embedded in the pathogenic process that could help classifying the disease and predicting its heterogeneous outcome beyond inflammation dynamics.
In this review, we summarize current knowledge on the multiple roles that B cells play in several aspects of RA.
We also analyze their distribution and potential function in different anatomic compartments with specific reference to the main sites in which the disease may be sustained and exert its detrimental effects: the systemic circulation, synovium, bone marrow, and draining lymph nodes.
We also highlight novel data encouraging further research in the field of biomarkers related to B cells and their regulatory factors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bugatti, Serena& Vitolo, Barbara& Caporali, Roberto& Montecucco, Carlomaurizio& Manzo, Antonio. 2014. B Cells in Rheumatoid Arthritis : From Pathogenic Players to Disease Biomarkers. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-490093
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bugatti, Serena…[et al.]. B Cells in Rheumatoid Arthritis : From Pathogenic Players to Disease Biomarkers. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-490093
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bugatti, Serena& Vitolo, Barbara& Caporali, Roberto& Montecucco, Carlomaurizio& Manzo, Antonio. B Cells in Rheumatoid Arthritis : From Pathogenic Players to Disease Biomarkers. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-490093
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490093
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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