![](/images/graphics-bg.png)
Dehydroabietic Acid Derivative QC2 Induces Oncosis in Hepatocellular Carcinoma Cells
المؤلفون المشاركون
Gu, Wen
Jiang, Chunping
Ding, Yitao
Chen, Weibo
Wang, Zhongxia
Zhang, Guang
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Aim.
Rosin, the traditional Chinese medicine, is reported to be able to inhibit skin cancer cell lines.
In this report, we investigate the inhibitory effect against HCC cells of QC2, the derivative of rosin’s main components dehydroabietic acid.
Methods.
MTT assay was used to determine the cytotoxicity of QC2.
Morphological changes were observed by time-lapse microscopy and transmission electron microscopy and the cytoskeleton changes were observed by laser-scanning confocal microscopy.
Cytomembrane integrity and organelles damage were confirmed by detection of the reactive oxygen (ROS), lactate dehydrogenase (LDH), and mitochondrial membrane potential (Δψm).
The underlying mechanism was manifested by Western blotting.
The oncotic cell death was further confirmed by detection of oncosis related protein calpain.
Results.
Swelling cell type and destroyed cytoskeleton were observed in QC2-treated HCC cells.
Organelle damage was visualized by transmission electron microscopy.
The detection of ROS accumulation, increased LDH release, and decreased ATP and Δψm confirmed the cell death.
The oncotic related protein calpain was found to increase time-dependently in QC2-treated HCC cells, while its inhibitor PD150606 attenuated the cytotoxicity.
Conclusions.
Dehydroabietic acid derivative QC2 activated oncosis related protein calpain to induce the damage of cytomembrane and organelles which finally lead to oncosis in HCC cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Guang& Jiang, Chunping& Wang, Zhongxia& Chen, Weibo& Gu, Wen& Ding, Yitao. 2014. Dehydroabietic Acid Derivative QC2 Induces Oncosis in Hepatocellular Carcinoma Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-490148
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Guang…[et al.]. Dehydroabietic Acid Derivative QC2 Induces Oncosis in Hepatocellular Carcinoma Cells. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-490148
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Guang& Jiang, Chunping& Wang, Zhongxia& Chen, Weibo& Gu, Wen& Ding, Yitao. Dehydroabietic Acid Derivative QC2 Induces Oncosis in Hepatocellular Carcinoma Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-490148
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490148
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)