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Scorpion in Combination with Gypsum : Novel Antidiabetic Activities in Streptozotocin-Induced Diabetic Mice by Up-Regulating Pancreatic PPARγ and PDX-1 Expressions
المؤلفون المشاركون
Zhao, Yunan
Xie, Weidong
Zhang, Yaou
Cai, Guoping
Gu, Dayong
Xing, Dong-Ming
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-04-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The management of diabetes without any side effects remains a challenge in medicine.
In this study, antidiabetic activity and the mechanism of action of scorpion combined with gypsum (SG) were investigated.
Streptozotocin-induced diabetic mice were orally administrated with scorpion (200 mg kg−1 per day) in combination with gypsum (200 mg kg−1 per day) for 5 weeks.
SG treatment resulted in decreased body weight, blood glucose and lipid levels, and increased serum and pancreatic insulin levels in diabetic mice.
Furthermore, SG significantly increased the number and volume of beta cells in the Islets of Langerhans and promoted peroxisome proliferator-activated receptor gamma and pancreatic duodenal homeobox 1 expressions in pancreatic tissues.
However, scorpion or gypsum alone had no significant effect in this animal model.
Metformin showed a slight or moderate effect in this diabetic model, but this effect was weak compared with that of SG.
Taken together, SG showed a new antidiabetic effect in streptozotocin-induced diabetic mice.
This effect may possibly be involved in enhancing beta-cell regeneration and promoting insulin secretion by targeting PPARγ and PDX-1.
Moreover, this new effect of SG offers a promising step toward the treatment of diabetic patients with beta-cell failure as a complementary and alternative medicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xie, Weidong& Zhao, Yunan& Gu, Dayong& Xing, Dong-Ming& Cai, Guoping& Zhang, Yaou. 2011. Scorpion in Combination with Gypsum : Novel Antidiabetic Activities in Streptozotocin-Induced Diabetic Mice by Up-Regulating Pancreatic PPARγ and PDX-1 Expressions. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-490262
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xie, Weidong…[et al.]. Scorpion in Combination with Gypsum : Novel Antidiabetic Activities in Streptozotocin-Induced Diabetic Mice by Up-Regulating Pancreatic PPARγ and PDX-1 Expressions. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-490262
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xie, Weidong& Zhao, Yunan& Gu, Dayong& Xing, Dong-Ming& Cai, Guoping& Zhang, Yaou. Scorpion in Combination with Gypsum : Novel Antidiabetic Activities in Streptozotocin-Induced Diabetic Mice by Up-Regulating Pancreatic PPARγ and PDX-1 Expressions. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-490262
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490262
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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