The Angiogenic Activity of Ascites in the Course of Ovarian Cancer as a Marker of Disease Progression
المؤلفون المشاركون
Szewczyk, Grzegorz
Szukiewicz, Dariusz
Barcz, Ewa
Skopiński, Piotr
Małecki, Maciej
Śmiertka, Wacław
Miedzińska-Maciejewska, Magdalena
Kamiński, Paweł
Skopińska-Różewska, Ewa
Gawrychowski, Krzysztof
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-23
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Ovarian cancer cells are able to create invasive implants in the peritoneum and their growth is directly associated with the angiogenetic potential.
This effect is probably stimulated by vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8), which are both found in ascites.
The aim of this study was to assess the influence of ascites produced by ovarian cancer on the angiogenesis.
Peritoneal fluid was collected from patients with advanced ovarian cancer; cancer cells were separated from CD45+ leukocytes.
Angiogenesis was assessed in mice, after intradermal injection of full cellular suspension together with supernatant or phosphate buffered saline, purified cancer cells suspension, or CD45+ leukocytes suspension.
The angiogenesis index (AI) was assessed after 72 hours.
VEGF and Il-8 were measured in the supernatant and cellular suspension.
AI was the highest in the isolated cancer cells suspensions as well in the group stimulated with supernatant.
Both VEGF and IL-8 were high in supernatants from ascites rich in cancer cells (>45%).
A significant correlation was revealed between IL-8 concentration and AI.
We conclude that ascites in patients with advanced ovarian cancer stimulates angiogenesis and this mechanism is dependent mostly on cancer cells activity and enhanced by cooperation with infiltrating leukocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gawrychowski, Krzysztof& Szewczyk, Grzegorz& Skopińska-Różewska, Ewa& Małecki, Maciej& Barcz, Ewa& Kamiński, Paweł…[et al.]. 2014. The Angiogenic Activity of Ascites in the Course of Ovarian Cancer as a Marker of Disease Progression. Disease Markers،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-490281
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gawrychowski, Krzysztof…[et al.]. The Angiogenic Activity of Ascites in the Course of Ovarian Cancer as a Marker of Disease Progression. Disease Markers No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-490281
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gawrychowski, Krzysztof& Szewczyk, Grzegorz& Skopińska-Różewska, Ewa& Małecki, Maciej& Barcz, Ewa& Kamiński, Paweł…[et al.]. The Angiogenic Activity of Ascites in the Course of Ovarian Cancer as a Marker of Disease Progression. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-490281
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490281
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر