Management of the Hepatic Lymph Nodes during Resection of Liver Metastases from Colorectal Cancer : A Systematic Review
المؤلفون المشاركون
Davidson, Brian R.
Gurusamy, Kurinchi S.
Imber, Charles
المصدر
العدد
المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2007-08-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Hepatic lymph node involvement is generally considered a contraindication for liver resection performed for colorectal liver metastases.
However, some advocate hepatic lymphadenectomy in the presence of macroscopic involvement and others routine lymphadenectomy.
The aim of this review is to assess the role of lymphadenectomy in resection of liver metastases from colorectal cancer.
Methods.
Medline, Embase and Central databases were searched using a formal search strategy.
Trials with survival data with a minimum follow-up of 1 year were considered for inclusion.
Meta-analysis was performed using Revman.
Results.
A total of 4230 references were identified.
Ten reports of nine studies including 926 patients qualified for the review.
The prevalence of nodal metastases after routine lymphadenectomy was 16.3%.
The overall 3-year and 5-year survival rates in node-positive patients were 9/151 (11.3%) and 2/137 (1.5%), respectively, compared to 3-year and 5-year survival rates of 424/787 (53.9%) and 246/767 (32.1%) in node-negative patients.
The odds ratios for 3-year and 5-year survivals in node positive disease compared to node-negative disease were 0.12 (95% CI 0.06 to 0.24) and 0.08 (95% CI 0.03 to 0.22).
There was no randomized controlled trial which assessed the survival benefit of routine or “selective” lymphadenectomy.
Conclusion.
Currently, there is no evidence of survival benefit for routine or selective lymphadenectomy.
Survival rates are low in patients with positive lymph nodes draining the liver irrespective of whether they are detected by routine lymphadenectomy or by macroscopic involvement.
Further trials in this patient group are required.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gurusamy, Kurinchi S.& Imber, Charles& Davidson, Brian R.. 2007. Management of the Hepatic Lymph Nodes during Resection of Liver Metastases from Colorectal Cancer : A Systematic Review. HPB Surgery،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-490318
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gurusamy, Kurinchi S.…[et al.]. Management of the Hepatic Lymph Nodes during Resection of Liver Metastases from Colorectal Cancer : A Systematic Review. HPB Surgery No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-490318
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gurusamy, Kurinchi S.& Imber, Charles& Davidson, Brian R.. Management of the Hepatic Lymph Nodes during Resection of Liver Metastases from Colorectal Cancer : A Systematic Review. HPB Surgery. 2007. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-490318
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490318
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر