Management Strategies for Aggressive Cushing's Syndrome : From Macroadenomas to Ectopics
المؤلفون المشاركون
Graziadio, Chiara
Pozza, Carlotta
Giannetta, Elisa
Lenzi, Andrea
Isidori, Andrea Maria
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Cushing’s syndrome (CS) is a rare but severe clinical condition represented by an excessive endogenous cortisol secretion and hence excess circulating free cortisol, characterized by loss of the normal feedback regulation and circadian rhythm of the hypothalamic-pituitary axis due to inappropriate secretion of ACTH from a pituitary tumor (Cushing’s disease, CD) or an ectopic source (ectopic ACTH secretion, EAS).
The remaining causes (20%) are ACTH independent.
As soon as the diagnosis is established, the therapeutic goal is the removal of the tumor.
Whenever surgery is not curative, management of patients with CS requires a major effort to control hypercortisolemia and associated symptoms.
A multidisciplinary approach that includes endocrinologists, neurosurgeons, oncologists, and radiotherapists should be adopted.
This paper will focus on traditional and novel medical therapy for aggressive ACTH-dependent CS.
Several drugs are able to reduce cortisol levels.
Their mechanism of action involves blocking adrenal steroidogenesis (ketoconazole, metyrapone, aminoglutethimide, mitotane, etomidate) or inhibiting the peripheral action of cortisol through blocking its receptors (mifepristone “RU-486”).
Other drugs include centrally acting agents (dopamine agonists, somatostatin receptor agonists, retinoic acid, peroxisome proliferator-activated receptor γ “PPAR-γ” ligands) and novel chemotherapeutic agents (temozolomide and tyrosine kinase inhibitors) which have a significant activity against aggressive pituitary or ectopic tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pozza, Carlotta& Graziadio, Chiara& Giannetta, Elisa& Lenzi, Andrea& Isidori, Andrea Maria. 2012. Management Strategies for Aggressive Cushing's Syndrome : From Macroadenomas to Ectopics. Journal of Oncology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-490432
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pozza, Carlotta…[et al.]. Management Strategies for Aggressive Cushing's Syndrome : From Macroadenomas to Ectopics. Journal of Oncology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-490432
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pozza, Carlotta& Graziadio, Chiara& Giannetta, Elisa& Lenzi, Andrea& Isidori, Andrea Maria. Management Strategies for Aggressive Cushing's Syndrome : From Macroadenomas to Ectopics. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-490432
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490432
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر