Application of Multivariate Modeling for Radiation Injury Assessment : A Proof of Concept
المؤلفون المشاركون
Villa, Vilmar
Bolduc, David L.
Ledney, G. David
Bünger, Rolf
Blakely, William F.
Sandgren, David J.
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-06
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Multivariate radiation injury estimation algorithms were formulated for estimating severe hematopoietic acute radiation syndrome (H-ARS) injury (i.e., response category three or RC3) in a rhesus monkey total-body irradiation (TBI) model.
Classical CBC and serum chemistry blood parameters were examined prior to irradiation (d 0) and on d 7, 10, 14, 21, and 25 after irradiation involving 24 nonhuman primates (NHP) (Macaca mulatta) given 6.5-Gy 60Co Υ-rays (0.4 Gy min−1) TBI.
A correlation matrix was formulated with the RC3 severity level designated as the “dependent variable” and independent variables down selected based on their radioresponsiveness and relatively low multicollinearity using stepwise-linear regression analyses.
Final candidate independent variables included CBC counts (absolute number of neutrophils, lymphocytes, and platelets) in formulating the “CBC” RC3 estimation algorithm.
Additionally, the formulation of a diagnostic CBC and serum chemistry “CBC-SCHEM” RC3 algorithm expanded upon the CBC algorithm model with the addition of hematocrit and the serum enzyme levels of aspartate aminotransferase, creatine kinase, and lactate dehydrogenase.
Both algorithms estimated RC3 with over 90% predictive power.
Only the CBC-SCHEM RC3 algorithm, however, met the critical three assumptions of linear least squares demonstrating slightly greater precision for radiation injury estimation, but with significantly decreased prediction error indicating increased statistical robustness.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bolduc, David L.& Villa, Vilmar& Sandgren, David J.& Ledney, G. David& Blakely, William F.& Bünger, Rolf. 2014. Application of Multivariate Modeling for Radiation Injury Assessment : A Proof of Concept. Computational and Mathematical Methods in Medicine،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-490442
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bolduc, David L.…[et al.]. Application of Multivariate Modeling for Radiation Injury Assessment : A Proof of Concept. Computational and Mathematical Methods in Medicine No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-490442
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bolduc, David L.& Villa, Vilmar& Sandgren, David J.& Ledney, G. David& Blakely, William F.& Bünger, Rolf. Application of Multivariate Modeling for Radiation Injury Assessment : A Proof of Concept. Computational and Mathematical Methods in Medicine. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-490442
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490442
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر