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Blood Vessel-Derived Acellular Matrix for Vascular Graft Application
المؤلفون المشاركون
Conconi, Maria Teresa
Chioato, Tatiana
Guidi, Enrica
Bertalot, Thomas
Dall’Olmo, Luigi
Di Liddo, Rosa
Zanusso, Ilenia
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
To overcome the issues connected to the use of autologous vascular grafts and artificial materials for reconstruction of small diameter (<6 mm) blood vessels, this study aimed to develop acellular matrix- (AM-) based vascular grafts.
Rat iliac arteries were decellularized by a detergent-enzymatic treatment, whereas endothelial cells (ECs) were obtained through enzymatic digestion of rat skin followed by immunomagnetic separation of CD31-positive cells.
Sixteen female Lewis rats (8 weeks old) received only AM or previously in vitro reendothelialized AM as abdominal aorta interposition grafts (about 1 cm).
The detergent-enzymatic treatment completely removed the cellular part of vessels and both MHC class I and class II antigens.
One month after surgery, the luminal surface of implanted AMs was partially covered by ECs and several platelets adhered in the areas lacking cell coverage.
Intimal hyperplasia, already detected after 1 month, increased at 3 months.
On the contrary, all grafts composed by AM and ECs were completely covered at 1 month and their structure was similar to that of native vessels at 3 months.
Taken together, our findings show that prostheses composed of AM preseeded with ECs could be a promising approach for the replacement of blood vessels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dall’Olmo, Luigi& Zanusso, Ilenia& Di Liddo, Rosa& Chioato, Tatiana& Bertalot, Thomas& Guidi, Enrica…[et al.]. 2014. Blood Vessel-Derived Acellular Matrix for Vascular Graft Application. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-490455
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dall’Olmo, Luigi…[et al.]. Blood Vessel-Derived Acellular Matrix for Vascular Graft Application. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-490455
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dall’Olmo, Luigi& Zanusso, Ilenia& Di Liddo, Rosa& Chioato, Tatiana& Bertalot, Thomas& Guidi, Enrica…[et al.]. Blood Vessel-Derived Acellular Matrix for Vascular Graft Application. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-490455
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490455
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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