Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway

المؤلفون المشاركون

Sun, Xiao-Bo
Yu, Yingli
Ma, Bo
Wang, Hongwei
Sun, Gui-Bo
Qin, Meng
Meng, Xiangbao
Chen, Rongchang
Ai, Qidi
Luo, Yun
Sun, Jing
Wang, Min

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-06-27

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

الطب البشري

الملخص EN

Reperfusion therapy is widely utilized for acute myocardial infarction (AMI), but further injury induced by rapidly initiating reperfusion of the heart is often encountered in clinical practice.

Ginsenoside RK3 (RK3) is reportedly present in the processed Radix notoginseng that is often used as a major ingredient of the compound preparation for ischemic heart diseases.

This study aimed to investigate the possible protective effect of RK3 against hypoxia-reoxygenation (H/R) induced H9c2 cardiomyocytes damage and its underlying mechanisms.

Our results showed that RK3 pretreatment caused increased cell viability and decreased levels of LDH leakage compared with the H/R group.

Moreover, RK3 pretreatment inhibited cell apoptosis, as evidenced by decreased caspase-3 activity, TUNEL-positive cells, and Bax expression, as well as increased Bcl-2 level.

Further mechanism investigation revealed that RK3 prevented H9c2 cardiomyocytes injury and apoptosis induced by H/R via AKT/Nrf-2/HO-1 and MAPK pathways.

These observations indicate that RK3 has the potential to exert cardioprotective effects against H/R injury, which might be of great importance to clinical efficacy for AMI treatment.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Sun, Jing& Sun, Gui-Bo& Meng, Xiangbao& Wang, Hongwei& Wang, Min& Qin, Meng…[et al.]. 2013. Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-490787

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Sun, Jing…[et al.]. Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-490787

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Sun, Jing& Sun, Gui-Bo& Meng, Xiangbao& Wang, Hongwei& Wang, Min& Qin, Meng…[et al.]. Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-490787

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-490787