Alternative Splicing Generates Different Parkin Protein Isoforms : Evidences in Human, Rat, and Mouse Brain
المؤلفون المشاركون
D'Agata, Velia
Scuderi, Soraya
Drago, Filippo
La Cognata, Valentina
Cavallaro, Sebastiano
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-16
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Parkinson protein 2, E3 ubiquitin protein ligase (PARK2) gene mutations are the most frequent causes of autosomal recessive early onset Parkinson’s disease and juvenile Parkinson disease.
Parkin deficiency has also been linked to other human pathologies, for example, sporadic Parkinson disease, Alzheimer disease, autism, and cancer.
PARK2 primary transcript undergoes an extensive alternative splicing, which enhances transcriptomic diversification.
To date several PARK2 splice variants have been identified; however, the expression and distribution of parkin isoforms have not been deeply investigated yet.
Here, the currently known PARK2 gene transcripts and relative predicted encoded proteins in human, rat, and mouse are reviewed.
By analyzing the literature, we highlight the existing data showing the presence of multiple parkin isoforms in the brain.
Their expression emerges from conflicting results regarding the electrophoretic mobility of the protein, but it is also assumed from discrepant observations on the cellular and tissue distribution of parkin.
Although the characterization of each predicted isoforms is complex, since they often diverge only for few amino acids, analysis of their expression patterns in the brain might account for the different pathogenetic effects linked to PARK2 gene mutations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Scuderi, Soraya& La Cognata, Valentina& Drago, Filippo& Cavallaro, Sebastiano& D'Agata, Velia. 2014. Alternative Splicing Generates Different Parkin Protein Isoforms : Evidences in Human, Rat, and Mouse Brain. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-490858
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Scuderi, Soraya…[et al.]. Alternative Splicing Generates Different Parkin Protein Isoforms : Evidences in Human, Rat, and Mouse Brain. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-490858
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Scuderi, Soraya& La Cognata, Valentina& Drago, Filippo& Cavallaro, Sebastiano& D'Agata, Velia. Alternative Splicing Generates Different Parkin Protein Isoforms : Evidences in Human, Rat, and Mouse Brain. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-490858
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490858
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر