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Employment of Oligodeoxynucleotide plus Interleukin-2 Improves Cytogenetic Analysis in Splenic Marginal Zone Lymphoma
المؤلفون المشاركون
Musto, Pellegrino
Abass, Awad E.
Tammiso, Elisa
Volta, Eleonora
Rigolin, Gian Matteo
Cuneo, Antonio
Pezzolo, Elisa
Cavazzini, Francesco
Rizzotto, Lara
D'Auria, Fiorella
Daghia, Giulia
Sofritti, Olga
Formigaro, Luca
Ambrosio, Cristina
Bardi, Antonella
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-05-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
To compare the efficiency of novel mitogenic agents and traditional mitosis inductors, 18 patients with splenic marginal zone lymphoma (SMZL) were studied.
Three cultures using oligodeoxynucleotide (ODN) plus interleukin-2 (IL-2), or TPA, or LPS were setup in each patient.
Seventeen/18 cases with ODN+IL2 had moderate/good proliferation (94,4%) as compared with 10/18 cases with TPA and LPS (55%) (P=.015); 14/18 (77,7%) cases with ODN+IL2 had sufficient good quality of banding as compared with 8/18 cases (44,4%) with TPA and LPS.
The karyotype could be defined from ODN+IL2-stimulated cultures in all 18 patients, 14 of whom (77,7%) had a cytogenetic aberration, whereas clonal aberrations could be documented in 9 and in 3 cases by stimulation with LPS and TPA, respectively.
Recurrent chromosome aberrations in our series were represented by aberrations of chromosome 14q in 5 patients, by trisomy 12 and 7q deletion in 4 cases each, and by abnormalities involving 11q and 13q in two cases each.
These findings show that stimulation with ODN+IL2 offers more mitotic figures of better quality and results in an increased rate of clonal aberrations in SMZL, making this method ideal for prospective studies aiming at the definition of the prognostic impact of cytogenetic aberrations in this disorder.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bardi, Antonella& Cavazzini, Francesco& Rigolin, Gian Matteo& Tammiso, Elisa& Volta, Eleonora& Pezzolo, Elisa…[et al.]. 2011. Employment of Oligodeoxynucleotide plus Interleukin-2 Improves Cytogenetic Analysis in Splenic Marginal Zone Lymphoma. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-490919
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bardi, Antonella…[et al.]. Employment of Oligodeoxynucleotide plus Interleukin-2 Improves Cytogenetic Analysis in Splenic Marginal Zone Lymphoma. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-490919
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bardi, Antonella& Cavazzini, Francesco& Rigolin, Gian Matteo& Tammiso, Elisa& Volta, Eleonora& Pezzolo, Elisa…[et al.]. Employment of Oligodeoxynucleotide plus Interleukin-2 Improves Cytogenetic Analysis in Splenic Marginal Zone Lymphoma. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-490919
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490919
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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