Malondialdehyde Adduct to Hemoglobin : A New Marker of Oxidative Stress Suitable for Full-Term and Preterm Neonates
المؤلفون المشاركون
Picaud, Jean-Charles
Steghens, Jean-Paul
Haÿs, Stéphane
Cipierre, Cécile
Maucort-Boulch, Delphine
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-13
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Oxidative stress may play a central role in the onset of many diseases during the neonatal period.
Malondialdehyde (MDA) is a marker of lipid peroxidation.
The aim of this study was to evaluate a new marker, the malondialdehyde adduct to hemoglobin (MDA-Hb), which is measured in red blood cells (RBCs) and thus does not require that an additional blood sample be drawn.
In this prospective study, we first adapted the measurement method previously described to Hb solutions obtained from washed RBCs and then evaluated the suitability of the method for use in neonates.
MDA-Hb concentrations were measured by liquid chromatography-mass spectrometry.
We compared the concentrations of MDA-Hb between preterm and term neonates.
Erythrocyte samples were collected at birth from 60 healthy neonates (29 full-term and 31 preterm), as well as from 50 preterm neonates with uncomplicated postnatal evolution during the first months of life.
We found a significantly higher MDA-Hb concentration at birth in preterm neonates (P=0.002).
During the first months of life, MDA-Hb concentrations were 9.4 nanomol/g Hb in hospitalized preterm neonates.
MDA-Hb could be used to assess oxidative stress in preterm neonates.
Together with clinical variables, it could be a useful marker for oxidative stress exposition in these higher risk patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cipierre, Cécile& Haÿs, Stéphane& Maucort-Boulch, Delphine& Steghens, Jean-Paul& Picaud, Jean-Charles. 2013. Malondialdehyde Adduct to Hemoglobin : A New Marker of Oxidative Stress Suitable for Full-Term and Preterm Neonates. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-491150
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cipierre, Cécile…[et al.]. Malondialdehyde Adduct to Hemoglobin : A New Marker of Oxidative Stress Suitable for Full-Term and Preterm Neonates. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-491150
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cipierre, Cécile& Haÿs, Stéphane& Maucort-Boulch, Delphine& Steghens, Jean-Paul& Picaud, Jean-Charles. Malondialdehyde Adduct to Hemoglobin : A New Marker of Oxidative Stress Suitable for Full-Term and Preterm Neonates. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-491150
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491150
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر