Microscopic Varicocelectomy Significantly Decreases the Sperm DNA Fragmentation Index in Patients with Infertility
المؤلفون المشاركون
Celtik, Murad
Aliyev, Emin
Kadioglu, Teoman Cem
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-10
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Background.
Varicocele is associated with high levels of DNA damage in spermatozoa due to oxidative stress and elevated levels of sperm DNA fragmentation, which has been currently proposed to be an essential additional diagnostic test to be recommended for patients with clinical varicocele.
The aim of this study was to evaluate the parameters of semen and the DNA fragmentation index (DFI) in patients with varicocele before and after varicocelectomy.
Methods.
The details of 92 consecutive patients were retrospectively analyzed from January 2010 to December 2012.
The sperm samples were evaluated according to the World Health Organization Guidelines.
Sperm DNA damage, characterized as DFI, was evaluated by sperm chromatin structure assay using flow cytometry.
Results.
There was a statistically significant improvement in the semen concentration, the total motile count, the total normal sperm count, and the sperm DNA fragmentation index (DFI; the percentage of sperm with denatured DNA) after varicocelectomy.
There was a large decrease in DFI from a preoperative mean of 42.6% to a postoperative mean of 20.5% (P<0.001).
A higher preoperative DFI was associated with a larger decrease in postoperative DFI, and significant negative correlations were observed between the DFI and sperm motility (r=-0.42, P<0.01).
Conclusion.
Our data suggest that varicocelectomy can improve multiple semen parameters and sperm DNA damage in infertile men with varicocele.
The patients with preoperative defects in those parameters showed greater improvement postoperatively.
Further research in this area is needed to understand the exact mechanisms of DNA damage in infertile men with varicocele.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kadioglu, Teoman Cem& Aliyev, Emin& Celtik, Murad. 2014. Microscopic Varicocelectomy Significantly Decreases the Sperm DNA Fragmentation Index in Patients with Infertility. BioMed Research International،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-491290
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kadioglu, Teoman Cem…[et al.]. Microscopic Varicocelectomy Significantly Decreases the Sperm DNA Fragmentation Index in Patients with Infertility. BioMed Research International No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-491290
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kadioglu, Teoman Cem& Aliyev, Emin& Celtik, Murad. Microscopic Varicocelectomy Significantly Decreases the Sperm DNA Fragmentation Index in Patients with Infertility. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-491290
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491290
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر