A Novel, Sensitive Assay for Behavioral Defects in Parkinson's Disease Model Drosophila
المؤلفون المشاركون
Gazit, Ehud
Ringo, John
Menuchin, Yotam
Segal, Daniel
Shaltiel-Karyo, Ronit
Frenkel-Pinter, Moran
Davidi, Dan
Marcus-Kalish, Mira
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-25
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Parkinson's disease is a common neurodegenerative disorder with the pathology of α-synuclein aggregation in Lewy bodies.
Currently, there is no available therapy that arrests the progression of the disease.
Therefore, the need of animal models to follow α-synuclein aggregation is crucial.
Drosophila melanogaster has been researched extensively as a good genetic model for the disease, with a cognitive phenotype of defective climbing ability.
The assay for climbing ability has been demonstrated as an effective tool for screening new therapeutic agents for Parkinson's disease.
However, due to the assay's many limitations, there is a clear need to develop a better behavioral test.
Courtship, a stereotyped, ritualized behavior of Drosophila, involves complex motor and sensory functions in both sexes, which are controlled by large number of neurons; hence, behavior observed during courtship should be sensitive to disease processes in the nervous system.
We used a series of traits commonly observed in courtship and an additional behavioral trait—nonsexual encounters—and analyzed them using a data mining tool.
We found defective behavior of the Parkinson's model male flies that were tested with virgin females, visible at a much younger age than the climbing defects.
We conclude that this is an improved behavioral assay for Parkinson's model flies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shaltiel-Karyo, Ronit& Davidi, Dan& Menuchin, Yotam& Frenkel-Pinter, Moran& Marcus-Kalish, Mira& Ringo, John…[et al.]. 2012. A Novel, Sensitive Assay for Behavioral Defects in Parkinson's Disease Model Drosophila. Journal of Obesity،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-491455
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shaltiel-Karyo, Ronit…[et al.]. A Novel, Sensitive Assay for Behavioral Defects in Parkinson's Disease Model Drosophila. Journal of Obesity No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-491455
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shaltiel-Karyo, Ronit& Davidi, Dan& Menuchin, Yotam& Frenkel-Pinter, Moran& Marcus-Kalish, Mira& Ringo, John…[et al.]. A Novel, Sensitive Assay for Behavioral Defects in Parkinson's Disease Model Drosophila. Journal of Obesity. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-491455
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491455
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر