Rhodiola rosea Impairs Acquisition and Expression of Conditioned Place Preference Induced by Cocaine
المؤلفون المشاركون
Perfumi, Marina
Manzanedo, Carmen
Mattioli, Laura
Rodríguez-Arias, Marta
Miñarro, José
Titomanlio, Federica
Aguilar, María A.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
A novel approach to the treatment of adverse effects of drugs of abuse is one which makes use of natural products.
The present study investigated the effect of Rhodiola rosea L.
hydroalcoholic extract (RHO) on cocaine-induced hyperactivity and conditioned place preference (CPP) in mice.
In a first experiment, mice received RHO (15, 20 or 25 mg/kg, IG), cocaine (25 mg/kg, i.p.) (COC), or a combination of both drugs (COC + RHO15, COC + RHO20, and COC + RHO25), and their locomotor activity was evaluated.
In a second experiment, the effects of RHO on the acquisition, expression, and reinstatement of cocaine CPP (induced by drug priming or social defeat stress) were evaluated.
RHO alone did not increase activity but potentiated the hyperactivity induced by cocaine.
Rhodiola did not induce motivational effects by itself but attenuated the acquisition and expression of cocaine-induced CPP.
Moreover, it was found that RHO did not block reinstatement.
The results indicate that RHO is effective in reducing the rewarding properties of cocaine but is ineffective in preventing priming or stress-induced cocaine reinstatement.
In light of these findings, the benefits of Rhodiola rosea L.
as a treatment of cocaine addiction would seem to be limited.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Titomanlio, Federica& Manzanedo, Carmen& Rodríguez-Arias, Marta& Mattioli, Laura& Perfumi, Marina& Miñarro, José…[et al.]. 2013. Rhodiola rosea Impairs Acquisition and Expression of Conditioned Place Preference Induced by Cocaine. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-491463
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Titomanlio, Federica…[et al.]. Rhodiola rosea Impairs Acquisition and Expression of Conditioned Place Preference Induced by Cocaine. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-491463
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Titomanlio, Federica& Manzanedo, Carmen& Rodríguez-Arias, Marta& Mattioli, Laura& Perfumi, Marina& Miñarro, José…[et al.]. Rhodiola rosea Impairs Acquisition and Expression of Conditioned Place Preference Induced by Cocaine. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-491463
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491463
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر