Angiotensin-Converting Enzyme Genotype and Peripheral Arterial Disease in Diabetic Patients
المؤلفون المشاركون
Chong, Choon-Khim
Tseng, Farn-Hsuan
Tseng, Ching-Ping
Tseng, Chin-Hsiao
Cheng, Ju-Chien
المصدر
Experimental Diabetes Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-11-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
We investigated the effect of traditional risk factors (hypertension, dyslipidemia and smoking) on the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and peripheral arterial disease (PAD) in 945 (454 men and 491 women) Taiwanese type 2 diabetic patients with a mean age of 63.5 (SD: 11.4) years.
Among them, 81 (31 men and 50 women) had PAD (ankle-brachial index <0.9).
The adjusted odds ratios (95% confidence intervals) were 2.48 (1.18–5.21), 1.69 (1.00–2.85) and 1.64 (1.12–2.39), respectively, for recessive (DD versus II + ID), dominant (DD + ID versus II) and additive (II = 0, ID = 1 and DD = 2) models.
While analyzing the interaction between DD and the individual risk factor of hypertension, smoking and dyslipidemia, patients with the risk factor and with DD had the highest risk compared to referent patients without the risk factor and with II/ID.
The respective adjusted odds ratios were 5.41 (2.05–14.31), 7.38 (1.87–29.06) and 4.64 (1.70–12.64).
We did not find a significant interaction between DD and any of the risk factors under multiplicative or additive scale.
In conclusion, traditional risk factors (hypertension, smoking and dyslipidemia) play an important role in the association between ACE genotypes and PAD.
Patients with DD genotype and traditional risk factors are at the highest risk.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tseng, Chin-Hsiao& Tseng, Farn-Hsuan& Chong, Choon-Khim& Tseng, Ching-Ping& Cheng, Ju-Chien. 2011. Angiotensin-Converting Enzyme Genotype and Peripheral Arterial Disease in Diabetic Patients. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-491567
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tseng, Chin-Hsiao…[et al.]. Angiotensin-Converting Enzyme Genotype and Peripheral Arterial Disease in Diabetic Patients. Experimental Diabetes Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-491567
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tseng, Chin-Hsiao& Tseng, Farn-Hsuan& Chong, Choon-Khim& Tseng, Ching-Ping& Cheng, Ju-Chien. Angiotensin-Converting Enzyme Genotype and Peripheral Arterial Disease in Diabetic Patients. Experimental Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-491567
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491567
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر