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Clinical Characteristics of Turkish Women with Candida krusei Vaginitis and Antifungal Susceptibility of the C. krusei Isolates
المؤلفون المشاركون
Aydın, Merve
Kalkancı, Ayşe
Ilkit, Macit
Meral, Melda
Güzel, Ahmet Bariş
المصدر
Infectious Diseases in Obstetrics and Gynecology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Candida krusei causes approximately 1% of vulvovaginal candidiasis (VVC) cases and is naturally resistant to fluconazole.
Antifungal testing may be required if C.
krusei vaginitis fails to respond to non-fluconazole therapy, particularly in patients with recurrent infections.
Design.
We investigated the clinical characteristics and antifungal susceptibility profile of vaginal C.
krusei isolates.
Between 2009 and 2012, we identified 560 unrelated Candida spp.-positive vaginal cultures, of which 28 (5.0%) were C.
krusei.
These isolates were analyzed according to host factors and the clinical forms of VVC, and their in vitro susceptibility to 10 antifungal agents was tested using a reference microdilution method.
Results.
We observed that perineal laceration and increased age (>50 years) were significant predictors of C.
krusei in vaginal samples (P<0.05).
All isolates were susceptible to amphotericin B, caspofungin, ketoconazole, and miconazole.
Additionally, susceptible dose-dependent and resistant rates were found for fluconazole as 42.9% and 57.1%, respectively.
Remarkably, only 42.9% and 67.9% of the isolates were susceptible to itraconazole and voriconazole, respectively.
Conclusions.
Understanding local susceptibility patterns, especially those of non-C.
albicans Candida species, can significantly aid in the selection of an effective antifungal agent.
The in vivo response of C.
krusei vaginitis to various antifungal therapeutics remains unknown and requires further research.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Güzel, Ahmet Bariş& Aydın, Merve& Meral, Melda& Kalkancı, Ayşe& Ilkit, Macit. 2013. Clinical Characteristics of Turkish Women with Candida krusei Vaginitis and Antifungal Susceptibility of the C. krusei Isolates. Infectious Diseases in Obstetrics and Gynecology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-491573
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Güzel, Ahmet Bariş…[et al.]. Clinical Characteristics of Turkish Women with Candida krusei Vaginitis and Antifungal Susceptibility of the C. krusei Isolates. Infectious Diseases in Obstetrics and Gynecology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-491573
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Güzel, Ahmet Bariş& Aydın, Merve& Meral, Melda& Kalkancı, Ayşe& Ilkit, Macit. Clinical Characteristics of Turkish Women with Candida krusei Vaginitis and Antifungal Susceptibility of the C. krusei Isolates. Infectious Diseases in Obstetrics and Gynecology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-491573
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491573
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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