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Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells
المؤلفون المشاركون
Castater, Christine A.
Adami, Alexander J.
Schramm, Craig M.
Secor, Eric R.
Rafti, Ektor T.
Natarajan, Prabitha
Thrall, Roger S.
McNamara, Jeffrey T.
Matson, Adam P.
Szczepanek, Steven M.
Guernsey, Linda
Silbart, Lawrence K.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The incidence of atopic conditions has increased in industrialized countries.
Persisting symptoms and concern for drug side-effects lead patients toward adjunctive treatments such as phytotherapy.
Previously, we have shown that Bromelain (sBr), a mixture of cysteine proteases from pineapple, Ananas comosus, inhibits ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).
However, sBr’s effect on development of AAD when treatment is administered throughout OVA-alum sensitization was unknown and is the aim of the present study.
C57BL/6J mice were sensitized with OVA/alum and challenged with 7 days OVA aerosol.
sBr 6 mg/kg/0.5 ml or PBS vehicle were administered throughout sensitization.
Lung, bronchoalveolar lavage (BAL), spleen, and lymph nodes were processed for flow cytometry and OVA-specific IgE was determined via ELISA.
sBr treatment throughout OVA-alum sensitization significantly reduced the development of AAD (BAL eosinophils and lymphocytes).
OVA-specific IgE and OVA TET+ cells were decreased.
sBr reduced CD11c+ dendritic cell subsets, and in vitro treatment of DCs significantly reduced CD44, a key receptor in both cell trafficking and activation.
sBr was shown to reduce allergic sensitization and the generation of AAD upon antigen challenge.
These results provide additional insight into sBr's anti-inflammatory and antiallergic properties and rationale for translation into the clinical arena.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Secor, Eric R.& Szczepanek, Steven M.& Castater, Christine A.& Adami, Alexander J.& Matson, Adam P.& Rafti, Ektor T.…[et al.]. 2013. Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-491708
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Secor, Eric R.…[et al.]. Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-491708
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Secor, Eric R.& Szczepanek, Steven M.& Castater, Christine A.& Adami, Alexander J.& Matson, Adam P.& Rafti, Ektor T.…[et al.]. Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-491708
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491708
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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