![](/images/graphics-bg.png)
Monitoring Drug and Antidrug Levels : A Rational Approach in Rheumatoid Arthritis Patients Treated with Biologic Agents Who Experience Inadequate Response While Being on a Stable Biologic Treatment
المؤلفون المشاركون
Mazilu, Diana
Opriş, Daniela
Borangiu, Andreea
Saulescu, Ioana
Predeteanu, Denisa
Apetrei, Natalia
Ionescu, Ruxandra
Bojinca, Violeta
Groseanu, Laura
Balanescu, Andra
Peltea, Alexandra
Luca, Giorgiana
Gudu, Tania
Gainaru, Cecilia
Iliuta, Mihaela
Constantinescu, Cosmin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Clinical response in patients with rheumatoid arthritis (RA) treated with biologic agents can be influenced by their pharmacokinetics and immunogenicity.
The present study evaluated the concordance between serum drug and antidrug levels as well as the clinical response in RA patients treated with biological agents who experience their first disease exacerbation while being on a stable biologic treatment.
154 RA patients treated with rituximab (RTX), infliximab (IFX), adalimumab (ADL), or etanercept (ETN) were included.
DAS28, SDAI, and EULAR response were assessed at baseline and reevaluated at precise time intervals.
At the time of their first sign of inadequate response, patients were tested for both serum drug level and antidrug antibodies level.
At the next reevaluation, patients retreated with RTX that had detectable drug level had a better EULAR response (P=0.038) with lower DAS28 and SDAI scores (P=0.01 and P=0.03).
The same tendency was observed in patients treated with IFX and ETN regarding EULAR response (P=0.002 and P=0.023), DAS28 score (P=0.002 and P=0.003), and SDAI score (P=0.001 and P=0.026).
Detectable biologic drug levels correlated with a better clinical response in patients experiencing their first RA inadequate response while being on a stable biologic treatment with RTX, IFX, and ETN.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mazilu, Diana& Opriş, Daniela& Gainaru, Cecilia& Iliuta, Mihaela& Apetrei, Natalia& Luca, Giorgiana…[et al.]. 2014. Monitoring Drug and Antidrug Levels : A Rational Approach in Rheumatoid Arthritis Patients Treated with Biologic Agents Who Experience Inadequate Response While Being on a Stable Biologic Treatment. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-491748
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mazilu, Diana…[et al.]. Monitoring Drug and Antidrug Levels : A Rational Approach in Rheumatoid Arthritis Patients Treated with Biologic Agents Who Experience Inadequate Response While Being on a Stable Biologic Treatment. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-491748
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mazilu, Diana& Opriş, Daniela& Gainaru, Cecilia& Iliuta, Mihaela& Apetrei, Natalia& Luca, Giorgiana…[et al.]. Monitoring Drug and Antidrug Levels : A Rational Approach in Rheumatoid Arthritis Patients Treated with Biologic Agents Who Experience Inadequate Response While Being on a Stable Biologic Treatment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-491748
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491748
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)