Intravenous Iron Dextran as a Component of Anemia Management in Chronic Kidney Disease : A Report of Safety and Efficacy
المؤلفون المشاركون
Frinak, Stan
Yee, Jerry
Yessayan, Alexy
Sandhu, Ankur
Yessayan, Lenar
Besarab, Anatole
Zasuwa, Gerard
المصدر
International Journal of Nephrology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
We aimed to demonstrate safety and efficacy of intravenous (IV) low molecular weight iron dextran (LMWID) during treatment of anemic stage 3 and 4 chronic kidney disease (CKD) patients.
Methods.
Efficacy data was obtained by retrospective chart review of 150 consecutively enrolled patients.
Patients were assigned per protocol to oral or IV iron, with IV iron given to those with lower iron stores and/or hemoglobin.
Iron and darbepoetin were administered to achieve and maintain hemoglobin at 10–12 g/dL.
Efficacy endpoints were mean hemoglobin and change in iron indices approximately 30 and 60 days after enrollment.
Safety data was obtained by retrospective review of reported adverse drug events (ADEs) following 1699 infusions of LMWID (0.5–1.0 g).
Results.
Mean hemoglobin, iron saturation, and ferritin increased significantly from baseline to 60 days in patients assigned to LMWID (hemoglobin: 11.3 versus 9.4 g/dL; iron saturation: 24% versus 12.9%; ferritin: 294.7 versus 134.7 ng/mL; all P values<0.0001).
Iron stores and hemoglobin were maintained in the group assigned to oral iron.
Of 1699 iron dextran infusions, three ADEs occurred.
Conclusions.
Treatment of anemia in CKD stages 3 and 4 with LMWID and darbepoetin is efficacious.
The serious ADE rate was 0.06% per infusion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yessayan, Lenar& Sandhu, Ankur& Besarab, Anatole& Yessayan, Alexy& Frinak, Stan& Zasuwa, Gerard…[et al.]. 2013. Intravenous Iron Dextran as a Component of Anemia Management in Chronic Kidney Disease : A Report of Safety and Efficacy. International Journal of Nephrology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-491788
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yessayan, Lenar…[et al.]. Intravenous Iron Dextran as a Component of Anemia Management in Chronic Kidney Disease : A Report of Safety and Efficacy. International Journal of Nephrology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-491788
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yessayan, Lenar& Sandhu, Ankur& Besarab, Anatole& Yessayan, Alexy& Frinak, Stan& Zasuwa, Gerard…[et al.]. Intravenous Iron Dextran as a Component of Anemia Management in Chronic Kidney Disease : A Report of Safety and Efficacy. International Journal of Nephrology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-491788
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491788
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر