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Nevirapine-Based Antiretroviral Therapy Impacts Artesunate and Dihydroartemisinin Disposition in HIV-Infected Nigerian Adults
المؤلفون المشاركون
Akinola, Ibrahim Tope
Murphy, Robert L.
Fehintola, Fatai A.
Akinyinka, Olusegun O.
Scarsi, Kimberly K.
Morse, Gene D.
Lindegardh, Niklas
Ojengbede, Oladosu
Aweeka, Francesca T.
Ma, Qing
Adewole, Isaac F.
Phakderaj, Aphiradee
Taiwo, Babafemi
Parikh, Sunil
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-05
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Nevirapine- (NVP-) based antiretroviral therapy (ART) and artesunate-amodiaquine are frequently coprescribed in areas of HIV and malaria endemicity.
We explored the impact of this practice on artesunate and dihydroartemisinin pharmacokinetics.
Methods.
We conducted a parallel-group pharmacokinetic comparison between HIV-infected patients receiving NVP-based ART (n=10) and ART-naive controls (n=11).
Artesunate-amodiaquine 200/600 mg was given daily for three days.
Measurement of drug concentrations occurred between 0 and 96 hours after the final dose.
Pharmacokinetic parameters were determined using noncompartmental analysis.
Results.
Comparing the NVP group to controls, clearance of artesunate was reduced 50% (1950 versus 2995 L/h; P=0.03), resulting in a 45% increase in the AUC0-96 (105 versus 69 ug∗hr/L; P=0.02).
The half-life of dihydroartemisinin was shorter in the NVP group (1.6 versuss 3.2 h; P=0.004), but other dihydroartemisinin pharmacokinetic parameters were unchanged.
A lower conversion of artesunate to dihydroartemisinin was observed in the NVP group (dihydroartemisinin: artesunate AUC0-96=5.6 versuss 8.5 in NVP and control groups, respectively, P=0.008).
Conclusion.
Although NVP-containing ART impacted some pharmacokinetic parameters of artesunate and dihydroartemisinin, overall exposure was similar or better in the NVP group.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fehintola, Fatai A.& Scarsi, Kimberly K.& Ma, Qing& Parikh, Sunil& Morse, Gene D.& Taiwo, Babafemi…[et al.]. 2012. Nevirapine-Based Antiretroviral Therapy Impacts Artesunate and Dihydroartemisinin Disposition in HIV-Infected Nigerian Adults. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-491834
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fehintola, Fatai A.…[et al.]. Nevirapine-Based Antiretroviral Therapy Impacts Artesunate and Dihydroartemisinin Disposition in HIV-Infected Nigerian Adults. AIDS Research and Treatment No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-491834
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fehintola, Fatai A.& Scarsi, Kimberly K.& Ma, Qing& Parikh, Sunil& Morse, Gene D.& Taiwo, Babafemi…[et al.]. Nevirapine-Based Antiretroviral Therapy Impacts Artesunate and Dihydroartemisinin Disposition in HIV-Infected Nigerian Adults. AIDS Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-491834
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491834
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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