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Artemether-Lumefantrine Combination Therapy for Treatment of Uncomplicated Malaria : The Potential for Complex Interactions with Antiretroviral Drugs in HIV-Infected Individuals
المؤلفون المشاركون
Byakika-Kibwika, Pauline
Mayanja-Kizza, Harriet
Khoo, Saye
Van geertruyden, Jean-Pierre
Lamorde, Mohammed
Merry, Concepta
المصدر
Malaria Research and Treatment
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-04-06
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Treatment of malaria in HIV-infected individuals receiving antiretroviral therapy (ART) poses significant challenges.
Artemether-lumefantrine (AL) is one of the artemisisnin-based combination therapies recommended for treatment of malaria.
The drug combination is highly efficacious against sensitive and multidrug resistant falciparum malaria.
Both artemether and lumefantrine are metabolized by hepatic cytochrome P450 (CYP450) enzymes which metabolize the protease inhibitors (PIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) used for HIV treatment.
Coadministration of NNRTIs and PIs with AL could potentially cause complex pharmacokinetic drug interactions.
NNRTI by inducing CYP450 3A4 enzyme and PIs by inhibiting CYP450 3A4 enzymes could influence both artemether and lumefantrine concentrations and their active metabolites dihydroartemisinin and desbutyl-lumefantrine, predisposing patients to poor treatment response, toxicity, and risk for development of resistance.
There are scanty data on these interactions and their consequences.
Pharmacokinetic studies to evaluate these interactions in the target populations are urgently needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Byakika-Kibwika, Pauline& Lamorde, Mohammed& Mayanja-Kizza, Harriet& Khoo, Saye& Merry, Concepta& Van geertruyden, Jean-Pierre. 2011. Artemether-Lumefantrine Combination Therapy for Treatment of Uncomplicated Malaria : The Potential for Complex Interactions with Antiretroviral Drugs in HIV-Infected Individuals. Malaria Research and Treatment،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-491845
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Byakika-Kibwika, Pauline…[et al.]. Artemether-Lumefantrine Combination Therapy for Treatment of Uncomplicated Malaria : The Potential for Complex Interactions with Antiretroviral Drugs in HIV-Infected Individuals. Malaria Research and Treatment No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-491845
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Byakika-Kibwika, Pauline& Lamorde, Mohammed& Mayanja-Kizza, Harriet& Khoo, Saye& Merry, Concepta& Van geertruyden, Jean-Pierre. Artemether-Lumefantrine Combination Therapy for Treatment of Uncomplicated Malaria : The Potential for Complex Interactions with Antiretroviral Drugs in HIV-Infected Individuals. Malaria Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-491845
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491845
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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