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Clinical Phenotypes of Patients with Anti-DFS70LEDGF Antibodies in a Routine ANA Referral Cohort
المؤلفون المشاركون
El Amri, Mohamed
Fritzler, Marvin J.
Musset, Lucile
Ghillani-Dalbin, Pascale
Charuel, Jean-Luc
Albesa, Roger
Amoura, Zahir
Mahler, Michael
Miyara, Makoto
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To analyze the clinical value of anti-DFS70 antibodies in a cohort of patients undergoing routine antinuclear antibodies (ANAs) testing.
Methods.
Sera with a dense fine speckled (DFS) indirect immunofluorescence (IIF) pattern from 100 consecutive patients and 100 patients with other IIF patterns were tested for anti-DFS70 antibodies by a novel chemiluminescence immunoassay (CIA) and for ANA by ANA Screen ELISA (both INOVA).
Results.
Among the 100 patients with a DFS IIF pattern, 91% were anti-DFS70 positive by CIA compared to 3% in the comparator group (P<0.0001).
The CIA and IIF titers of anti-DFS antibodies were highly correlated (rho = 0.89).
ANA by ELISA was positive in 35% of patients with the DFS IIF pattern as compared to 67% of patients with other patterns (P<0.0001).
Only 12.0% of patients with DFS pattern and 13.4% with DFS pattern and anti-DFS70 antibodies detected by CIA had systemic autoimmune rheumatic disease (SARD).
Only 5/91 (5.5%) patients with anti-DFS70 antibodies had SARD and their sera were negative on the ANA Screen ELISA.
Conclusion.
Although anti-DFS70 antibodies cannot exclude the presence of SARD, the likelihood is significantly lower than in patients with other IIF patterns and should be included in test algorithms for ANA testing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miyara, Makoto& Albesa, Roger& Charuel, Jean-Luc& El Amri, Mohamed& Fritzler, Marvin J.& Ghillani-Dalbin, Pascale…[et al.]. 2013. Clinical Phenotypes of Patients with Anti-DFS70LEDGF Antibodies in a Routine ANA Referral Cohort. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-491849
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miyara, Makoto…[et al.]. Clinical Phenotypes of Patients with Anti-DFS70LEDGF Antibodies in a Routine ANA Referral Cohort. Clinical and Developmental Immunology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-491849
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miyara, Makoto& Albesa, Roger& Charuel, Jean-Luc& El Amri, Mohamed& Fritzler, Marvin J.& Ghillani-Dalbin, Pascale…[et al.]. Clinical Phenotypes of Patients with Anti-DFS70LEDGF Antibodies in a Routine ANA Referral Cohort. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-491849
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491849
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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