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Cardiac Electrophysiological Alterations in HeartMuscle-Specific Manganese-Superoxide Dismutase-Deficient Mice : Prevention by a Dietary Antioxidant Polyphenol
المؤلفون المشاركون
Shirasawa, Takuji
Matsumoto, Akio
Shimizu, Takahiko
Tagashira, Motoyuki
Nakaya, Haruaki
Sunagawa, Tadahiro
Kanda, Tomomasa
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Cardiac electrophysiological alterations induced by chronic exposure to reactive oxygen species and protective effects of dietary antioxidant have not been thoroughly examined.
We recorded surface electrocardiograms (ECG) and evaluated cellular electrophysiological abnormalities in enzymatically-dissociated left ventricular (LV) myocytes in heart/muscle-specific manganese-superoxide dismutase-deficient (H/M-Sod2−/−) mice, which exhibit dilated cardiomyopathy due to increased oxidative stress.
We also investigated the influences of intake of apple polyphenols (AP) containing mainly procyanidins with potent antioxidant activity.
The QRS and QT intervals of ECG recorded in H/M-Sod2−/− mice were prolonged.
The effective refractory period in the LV myocardium of H/M-Sod2−/− mice was prolonged, and susceptibility to ventricular tachycardia or fibrillation induced by rapid ventricular pacing was increased.
Action potential duration in H/M-Sod2−/− LV myocytes was prolonged, and automaticity was enhanced.
The density of the inwardly rectifier K+ current (IK1) was decreased in the LV cells of H/M-Sod2−/− mice.
The AP intake partially improved these electrophysiological alterations and extended the lifespan in H/M-Sod2−/− mice.
Thus, chronic exposure of the heart to oxidative stress produces a variety of electrophysiological abnormalities, increased susceptibility to ventricular arrhythmias, and action potential changes associated with the reduced density of IK1.
Dietary intake of antioxidant nutrients may prevent oxidative stress-induced electrophysiological disturbances.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sunagawa, Tadahiro& Shimizu, Takahiko& Matsumoto, Akio& Tagashira, Motoyuki& Kanda, Tomomasa& Shirasawa, Takuji…[et al.]. 2014. Cardiac Electrophysiological Alterations in HeartMuscle-Specific Manganese-Superoxide Dismutase-Deficient Mice : Prevention by a Dietary Antioxidant Polyphenol. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-491913
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sunagawa, Tadahiro…[et al.]. Cardiac Electrophysiological Alterations in HeartMuscle-Specific Manganese-Superoxide Dismutase-Deficient Mice : Prevention by a Dietary Antioxidant Polyphenol. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-491913
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sunagawa, Tadahiro& Shimizu, Takahiko& Matsumoto, Akio& Tagashira, Motoyuki& Kanda, Tomomasa& Shirasawa, Takuji…[et al.]. Cardiac Electrophysiological Alterations in HeartMuscle-Specific Manganese-Superoxide Dismutase-Deficient Mice : Prevention by a Dietary Antioxidant Polyphenol. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-491913
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491913
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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