An NMR Study of the Bortezomib Degradation under Clinical Use Conditions
المؤلفون المشاركون
Pagliuca, Raffaella
Bolognese, Adele
Rotoli, Bruno
Catalano, Lucio
Petruzziello, Fara
Martorelli, Maria Carmen
Esposito, Anna
Scalfaro, Melania
Mazzarelli, Vittoria
Manfra, Michele
Ottiero, Maria
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-04-14
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl-boronic acid, bortezomib (BTZ), which binds the 20S proteasome subunit and causes a large inhibition of its activity, is a peptidomimetic boronic drug mainly used for the treatment of multiple myeloma.
Commercial BTZ, stabilized as mannitol derivative, has been investigated under the common conditions of the clinical use because it is suspected to be easily degradable in the region of its boronic moiety.
Commercial BTZ samples, reconstituted according to the reported commercial instructions and stored at 4∘C, were analyzed by high-field nuclear magnetic resonance spectroscopy in comparison with identical samples bubbled with air and argon, respectively.
All the samples remained unchanged for a week.
After a month, the air filled samples showed the presence of two main degradation products (6% of starting material), the N-(1-(1-hydroxy-3-methylbutylamino)-1-oxo-3-phenylpropan-2-yl) pyrazine-2-carboxamide (BTZ1; 5%, determined from NMR integration) and the (S)-N-(1-(3-methylbutanamido)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide (BTZ2; 1%, determined from NMR integration), identified on the basis of their chemical and spectroscopic properties.
The BTZ1 and BTZ2 finding suggests that, under the common condition of use and at 4∘C, commercial BTZ-mannitol is stable for a week, and that, in time, it undergoes slow oxidative deboronation which partially inactivates the product.
Low temperature and scarce contact with air decrease the degradation process.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bolognese, Adele& Esposito, Anna& Manfra, Michele& Catalano, Lucio& Petruzziello, Fara& Martorelli, Maria Carmen…[et al.]. 2009. An NMR Study of the Bortezomib Degradation under Clinical Use Conditions. Advances in Hematology،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-491958
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bolognese, Adele…[et al.]. An NMR Study of the Bortezomib Degradation under Clinical Use Conditions. Advances in Hematology No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-491958
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bolognese, Adele& Esposito, Anna& Manfra, Michele& Catalano, Lucio& Petruzziello, Fara& Martorelli, Maria Carmen…[et al.]. An NMR Study of the Bortezomib Degradation under Clinical Use Conditions. Advances in Hematology. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-491958
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491958
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر