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Comparison the Efficacy of Fluconazole and Terbinafine in Patients with Moderate to Severe Seborrheic Dermatitis
المؤلفون المشاركون
Kazemnejad, Ehsan
Darjani, Abbas
Golchai, Javad
Monadi Nori, Hamed
Alizadeh, Narges
Eshkevari, Shahriar S.
المصدر
Dermatology Research and Practice
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-18
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Topical agents can be unpleasant due to long-term therapies in patients with moderate to severe seborrheic dermatitis.
Systemic antifungal therapy is another alternative in treatment.
Aim.
This study was conducted to compare the efficacy of oral fluconazole and terbinafine in the treatment of moderate to severe seborrheic dermatitis.
Methods.
64 patients with moderate to severe seborrheic dermatitis (SD) were enrolled in a randomized, parallel-group study.
One study group took terbinafine 250 mg daily (n=32) and the other one fluconazole 300 mg (n=32) weekly for four weeks.
Seborrheic dermatitis area severity index (SDASI) and the intensity of itching were calculated before, at the end of treatment, and two weeks after treatment.
Results.
Both drugs significantly reduced the severity of seborrheic dermatitis (P<0.001).
Multivariate linear regression revealed that efficacy of terbinafine is more than fluconazole (P<0.01, 95% CI (0.63–4.7)).
Moreover, each index of SD severity reduced 0.9 times after treatment.
(P<0.002, 95% CI (0.8–1.02)).
The itching rate significantly diminished (P<0.001); however, there was no difference between these two drugs statistically.
Conclusions.
Both systemic antifungal therapies may reduce the severity index of SD.
However, terbinafine showed more reduction in the intensity of the disease.
In other words, the more the primary intensity of the disease is, the more its reduction will be.
This trial is resgistered with 201102205871N1.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alizadeh, Narges& Monadi Nori, Hamed& Golchai, Javad& Eshkevari, Shahriar S.& Kazemnejad, Ehsan& Darjani, Abbas. 2014. Comparison the Efficacy of Fluconazole and Terbinafine in Patients with Moderate to Severe Seborrheic Dermatitis. Dermatology Research and Practice،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-492017
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alizadeh, Narges…[et al.]. Comparison the Efficacy of Fluconazole and Terbinafine in Patients with Moderate to Severe Seborrheic Dermatitis. Dermatology Research and Practice No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-492017
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alizadeh, Narges& Monadi Nori, Hamed& Golchai, Javad& Eshkevari, Shahriar S.& Kazemnejad, Ehsan& Darjani, Abbas. Comparison the Efficacy of Fluconazole and Terbinafine in Patients with Moderate to Severe Seborrheic Dermatitis. Dermatology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-492017
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492017
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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