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The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis
المؤلفون المشاركون
Shuid, Ahmad Nazrun
Nadia, M. E.
Ima-Nirwana, Soelaiman
Mohamed, Norazlina
Muhammad, Norliza
Isa, N. M.
المصدر
Advances in Pharmacological Sciences
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Osteoporosis is characterized by skeletal degeneration with low bone mass and destruction of microarchitecture of bone tissue which is attributed to various factors including inflammation.
Women are more likely to develop osteoporosis than men due to reduction in estrogen during menopause which leads to decline in bone-formation and increase in bone-resorption activity.
Estrogen is able to suppress production of proinflammatory cytokines such as IL-1, IL-6, IL-7, and TNF-α.
This is why these cytokines are elevated in postmenopausal women.
Studies have shown that estrogen reduction is able to stimulate focal inflammation in bone.
Labisia pumila (LP) which is known to exert phytoestrogenic effect can be used as an alternative to ERT which can produce positive effects on bone without causing side effects.
LP contains antioxidant as well as exerting anti-inflammatory effect which can act as free radical scavenger, thus inhibiting TNF-α production and COX-2 expression which leads to decline in RANKL expression, resulting in reduction in osteoclast activity which consequently reduces bone loss.
Hence, it is the phytoestrogenic, anti-inflammatory, and antioxidative properties that make LP an effective agent against osteoporosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nadia, M. E.& Shuid, Ahmad Nazrun& Mohamed, Norazlina& Isa, N. M.& Muhammad, Norliza& Ima-Nirwana, Soelaiman. 2012. The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis. Advances in Pharmacological Sciences،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-492136
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nadia, M. E.…[et al.]. The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis. Advances in Pharmacological Sciences No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-492136
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nadia, M. E.& Shuid, Ahmad Nazrun& Mohamed, Norazlina& Isa, N. M.& Muhammad, Norliza& Ima-Nirwana, Soelaiman. The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis. Advances in Pharmacological Sciences. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-492136
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492136
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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