Immunology and Oxidative Stress in Multiple Sclerosis : Clinical and Basic Approach
المؤلفون المشاركون
Macías-Islas, Miguel Ángel
Flores-Alvarado, Luis J.
Ramírez-Anguiano, Ana C.
Pacheco Moisés, Fermín Paul
Bitzer-Quintero, Oscar K.
Torres-Sánchez, Erandis D.
Ortiz, Genaro Gabriel
Ramírez-Ramírez, Viridiana
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-24
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Multiple sclerosis (MS) exhibits many of the hallmarks of an inflammatory autoimmune disorder including breakdown of the blood-brain barrier (BBB), the recruitment of lymphocytes, microglia, and macrophages to lesion sites, the presence of multiple lesions, generally being more pronounced in the brain stem and spinal cord, the predominantly perivascular location of lesions, the temporal maturation of lesions from inflammation through demyelination, to gliosis and partial remyelination, and the presence of immunoglobulin in the central nervous system and cerebrospinal fluid.
Lymphocytes activated in the periphery infiltrate the central nervous system to trigger a local immune response that ultimately damages myelin and axons.
Pro-inflammatory cytokines amplify the inflammatory cascade by compromising the BBB, recruiting immune cells from the periphery, and activating resident microglia.
inflammation-associated oxidative burst in activated microglia and macrophages plays an important role in the demyelination and free radical-mediated tissue injury in the pathogenesis of MS.
The inflammatory environment in demyelinating lesions leads to the generation of oxygen- and nitrogen-free radicals as well as proinflammatory cytokines which contribute to the development and progression of the disease.
Inflammation can lead to oxidative stress and vice versa.
Thus, oxidative stress and inflammation are involved in a self-perpetuating cycle.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ortiz, Genaro Gabriel& Pacheco Moisés, Fermín Paul& Bitzer-Quintero, Oscar K.& Ramírez-Anguiano, Ana C.& Flores-Alvarado, Luis J.& Ramírez-Ramírez, Viridiana…[et al.]. 2013. Immunology and Oxidative Stress in Multiple Sclerosis : Clinical and Basic Approach. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-492283
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ortiz, Genaro Gabriel…[et al.]. Immunology and Oxidative Stress in Multiple Sclerosis : Clinical and Basic Approach. Clinical and Developmental Immunology No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-492283
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ortiz, Genaro Gabriel& Pacheco Moisés, Fermín Paul& Bitzer-Quintero, Oscar K.& Ramírez-Anguiano, Ana C.& Flores-Alvarado, Luis J.& Ramírez-Ramírez, Viridiana…[et al.]. Immunology and Oxidative Stress in Multiple Sclerosis : Clinical and Basic Approach. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-492283
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492283
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر