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Antioxidant Defense Enzyme Genes and Asthma Susceptibility : Gender-Specific Effects and Heterogeneity in Gene-Gene Interactions between Pathogenetic Variants of the Disease
المؤلفون المشاركون
Bogomazov, Alexey D.
Ivanov, Vladimir P.
Polonikov, Alexey V.
Solodilova, Maria A.
Illig, Thomas
Freidin, Maxim B.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-05
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Oxidative stress resulting from an increased amount of reactive oxygen species and an imbalance between oxidants and antioxidants plays an important role in the pathogenesis of asthma.
The present study tested the hypothesis that genetic susceptibility to allergic and nonallergic variants of asthma is determined by complex interactions between genes encoding antioxidant defense enzymes (ADE).
We carried out a comprehensive analysis of the associations between adult asthma and 46 single nucleotide polymorphisms of 34 ADE genes and 12 other candidate genes of asthma in Russian population using set association analysis and multifactor dimensionality reduction approaches.
We found for the first time epistatic interactions between ADE genes underlying asthma susceptibility and the genetic heterogeneity between allergic and nonallergic variants of the disease.
We identified GSR (glutathione reductase) and PON2 (paraoxonase 2) as novel candidate genes for asthma susceptibility.
We observed gender-specific effects of ADE genes on the risk of asthma.
The results of the study demonstrate complexity and diversity of interactions between genes involved in oxidative stress underlying susceptibility to allergic and nonallergic asthma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Polonikov, Alexey V.& Ivanov, Vladimir P.& Bogomazov, Alexey D.& Freidin, Maxim B.& Illig, Thomas& Solodilova, Maria A.. 2014. Antioxidant Defense Enzyme Genes and Asthma Susceptibility : Gender-Specific Effects and Heterogeneity in Gene-Gene Interactions between Pathogenetic Variants of the Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-492296
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Polonikov, Alexey V.…[et al.]. Antioxidant Defense Enzyme Genes and Asthma Susceptibility : Gender-Specific Effects and Heterogeneity in Gene-Gene Interactions between Pathogenetic Variants of the Disease. BioMed Research International No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-492296
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Polonikov, Alexey V.& Ivanov, Vladimir P.& Bogomazov, Alexey D.& Freidin, Maxim B.& Illig, Thomas& Solodilova, Maria A.. Antioxidant Defense Enzyme Genes and Asthma Susceptibility : Gender-Specific Effects and Heterogeneity in Gene-Gene Interactions between Pathogenetic Variants of the Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-492296
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492296
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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