Flow-Mediated Vasodilation Is Not Attenuated in Hypertensive Pregnancies Despite Biochemical Signs of Inflammation
المؤلفون المشاركون
Valtonen, Pirjo
Saarelainen, Heli
Lyyra-Laitinen, Tiina
Kärkkäinen, Henna
Vanninen, Esko
Laitinen, Tomi
Punnonen, Kari
Heinonen, Seppo
Heiskanen, Nonna
المصدر
ISRN Obstetrics and Gynecology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-01-17
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Our objective was to evaluate endothelial function and markers of inflammation during and after pregnancy in normal pregnancies compared to pregnancies complicated with hypertension or preeclampsia (PE).
Methods and Results.
We measured endothelium-dependent brachial artery flow-mediated vasodilation (FMD) and high sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6), and tumour necrosis factor-α (TNF-α) in 32 women with normal pregnancy and in 28 women whose pregnancy was complicated with hypertensive disorder in the second half of pregnancy and minimum 3-month postpartum.
Enhancement of endothelial function was greater in hypertensive than normal pregnancies, the mean FMD% being 11.0% versus 8.8% during pregnancy (P=0.194) and 8.0% versus 7.9% postpartum (P=0.978).
Concentrations of markers of inflammation were markedly increased in pregnant hypertensive group compared to those after delivery (hsCRP 4.5 versus 0.80 mg/L, P=0.023, IL-6 2.1 versus 1.2 pg/mL, P=0.006; TNF-α 1.9 versus 1.5 pg/mL, P=0.030).
There were no statistically significant associations between the markers of inflammation and FMD.
Conclusions.
Brachial artery FMD was not attenuated in the third trimester hypertensive pregnancies compared to normal pregnancies, whereas circulating concentrations of hsCRP and IL-6 and TNF-α reacted to hypertensive complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saarelainen, Heli& Kärkkäinen, Henna& Valtonen, Pirjo& Punnonen, Kari& Laitinen, Tomi& Heiskanen, Nonna…[et al.]. 2012. Flow-Mediated Vasodilation Is Not Attenuated in Hypertensive Pregnancies Despite Biochemical Signs of Inflammation. ISRN Obstetrics and Gynecology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-492348
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saarelainen, Heli…[et al.]. Flow-Mediated Vasodilation Is Not Attenuated in Hypertensive Pregnancies Despite Biochemical Signs of Inflammation. ISRN Obstetrics and Gynecology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-492348
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saarelainen, Heli& Kärkkäinen, Henna& Valtonen, Pirjo& Punnonen, Kari& Laitinen, Tomi& Heiskanen, Nonna…[et al.]. Flow-Mediated Vasodilation Is Not Attenuated in Hypertensive Pregnancies Despite Biochemical Signs of Inflammation. ISRN Obstetrics and Gynecology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-492348
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492348
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر