Correlations between Endothelial Functions and ROS Detection in Diabetic Microvascular Wall : Early and Late Ascorbic Acid Supplementation
المؤلفون المشاركون
Patumraj, Suthiluk
Sridulyakul, Pattarin
Wongeak-in, Natchaya
المصدر
International Journal of Vascular Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The correlation between endothelial function and reactive oxygen species detecting from diabetic microvascular wall and the antioxidant effect of ascorbic acid (AA) during early and late phases of diabetic induction were determined.
Male Spraque-Dawley rats were divided into four groups: control, diabetes rats (DM, using iv.injection of 55 mg/kg BW streptozotocin, (STZ)), and two groups of DM rats treated with AA (1 g/L, (STZ)) starting on day 2 (DM + AAday2) and week 6th (DM + AA6wk).
On 12th week after STZ injection, the findings showed that in DM group, Ach (10−5 M)-induced vasodilatation was decreased, while the number of leukocyte adhesion was increased significantly (P<0.01).
Interestingly, these abnormalities induced by DM could be protected or improved in both AA-treated groups, DM + AAday2 and DM + AA6wk.
By using dihydrorhodamine 123, our findings also indicated that the existing of ROS productions on diabetic arteriolar and venular walls were different significantly (ROSarteriole = 165.89 ± 24.59 and ROSvenule = 172.26 ± 34.70) (P<0.05).
Moreover by using BH4 inhibitor to induce increase in arteriolar ROS, the results also confirmed that AA could improve endothelial function with closed correlation to its potential to reduce vascular ROS content.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sridulyakul, Pattarin& Wongeak-in, Natchaya& Patumraj, Suthiluk. 2012. Correlations between Endothelial Functions and ROS Detection in Diabetic Microvascular Wall : Early and Late Ascorbic Acid Supplementation. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-492376
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sridulyakul, Pattarin…[et al.]. Correlations between Endothelial Functions and ROS Detection in Diabetic Microvascular Wall : Early and Late Ascorbic Acid Supplementation. International Journal of Vascular Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-492376
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sridulyakul, Pattarin& Wongeak-in, Natchaya& Patumraj, Suthiluk. Correlations between Endothelial Functions and ROS Detection in Diabetic Microvascular Wall : Early and Late Ascorbic Acid Supplementation. International Journal of Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-492376
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492376
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر