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HIV-Associated Central Nervous System Disease in Patients Admitted at the Douala General Hospital between 2004 and 2009 : A Retrospective Study
المؤلفون المشاركون
Tchaleu, Benjamin Clet Nguenkam
Temfack, Elvis
Njamnshi, Alfred Kinyuy
Ndenga, Daniela Pamela Ntchankam
Doualla, Marie Solange
Mapoure, Yacouba Njankouo
Luma, Henry Namme
Djientcheu, Vincent-de-Paul
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-26
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Studies on HIV-associated central nervous system (CNS) diseases in Cameroon are rare.
The aim of this study was to describe the clinical presentation, identify aetiological factors, and determine predictors of mortality in HIV patients with CNS disease.
Methods.
From January 1, 2004 and December 31, 2009, we did at the Douala General Hospital a clinical case note review of 672 admitted adult (age ≥ 18 years) HIV-1 patients, and 44.6% (300/672) of whom were diagnosed and treated for HIV-associated CNS disease.
Results.
The mean age of the study population was 38.1±13.5 years, and median CD4 count was 49 cells/mm3 (interquartile range (QR): 17–90).
The most common clinical presentations were headache (83%), focal signs (40.6%), and fever (37.7%).
Toxoplasma encephalitis and cryptococcal meningitis were the leading aetiologies of HIV-associated CNS disease in 32.3% and 25% of patients, respectively.
Overall mortality was 49%.
Primary central nervous system lymphoma (PCNSL) and bacterial meningitis had the highest case fatality rates of 100% followed by tuberculous meningitis (79.8%).
Low CD4 count was an independent predictor of fatality (AOR: 3.2, 95%CI: 2.0–5.2).
Conclusions.
HIV-associated CNS disease is common in Douala.
CNS symptoms in HIV patients need urgent investigation because of their association with diseases of high case fatality.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Luma, Henry Namme& Tchaleu, Benjamin Clet Nguenkam& Temfack, Elvis& Doualla, Marie Solange& Ndenga, Daniela Pamela Ntchankam& Mapoure, Yacouba Njankouo…[et al.]. 2013. HIV-Associated Central Nervous System Disease in Patients Admitted at the Douala General Hospital between 2004 and 2009 : A Retrospective Study. AIDS Research and Treatment،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-492390
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Luma, Henry Namme…[et al.]. HIV-Associated Central Nervous System Disease in Patients Admitted at the Douala General Hospital between 2004 and 2009 : A Retrospective Study. AIDS Research and Treatment No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-492390
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Luma, Henry Namme& Tchaleu, Benjamin Clet Nguenkam& Temfack, Elvis& Doualla, Marie Solange& Ndenga, Daniela Pamela Ntchankam& Mapoure, Yacouba Njankouo…[et al.]. HIV-Associated Central Nervous System Disease in Patients Admitted at the Douala General Hospital between 2004 and 2009 : A Retrospective Study. AIDS Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-492390
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492390
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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