Metronomic Cyclophosphamide and Methotrexate Chemotherapy Combined with 1E10 Anti-Idiotype Vaccine in Metastatic Breast Cancer
المؤلفون المشاركون
Vázquez López, Ana M.
Loys, Jorge L.
Batista, Noyde
Lima, Mayté
Macías, Amparo
Zarza, Yohanka
Soriano, Jorge L.
Aguirre, Frank
García, Robin
Santiesteban, Eduardo
Rodríguez, Myriam
González, Joaquín
Montejo, Narciso
López, María V.
المصدر
International Journal of Breast Cancer
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-07-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The use of low doses of cytotoxic agents continuously for prolonged periods is an alternative for the treatment of patients with metastatic breast cancer who have developed resistance to conventional chemotherapy.
The combination of metronomic chemotherapy with therapeutic vaccines might increase the efficacy of the treatment.
Twenty one patients with metastatic breast cancer in progression and a Karnosky index ≥60%, were treated with metronomic chemotherapy (50 mg of cyclophospamide orally daily and 2.5 mg of methotrexate orally bi-daily), in combination with five bi-weekly subcutaneous injections of 1 mg of aluminum hydroxide-precipitated 1E10 anti-idiotype MAb (1E10-Alum), followed by reimmunizations every 28 days.
Five patients achieved objective response, eight showed stable disease and eight had disease progression.
Median time to progression was 9,8 months, while median overall survival time was 12,93 months.
The median duration of the response (CR+PR+SD) was 18,43 months (12,20–24,10 months), being higher than 12 months in 76,9% of the patients.
Overall toxicity was generally mild.
Metronomic chemotherapy combined with 1E10-Alum vaccine immunotherapy might be a useful therapeutic option for the treatment of metastatic breast cancer due to its potential impact on survival and patient quality of live, low toxicity and advantages of the administration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Soriano, Jorge L.& Batista, Noyde& Santiesteban, Eduardo& Lima, Mayté& González, Joaquín& García, Robin…[et al.]. 2011. Metronomic Cyclophosphamide and Methotrexate Chemotherapy Combined with 1E10 Anti-Idiotype Vaccine in Metastatic Breast Cancer. International Journal of Breast Cancer،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-492420
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Soriano, Jorge L.…[et al.]. Metronomic Cyclophosphamide and Methotrexate Chemotherapy Combined with 1E10 Anti-Idiotype Vaccine in Metastatic Breast Cancer. International Journal of Breast Cancer No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-492420
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Soriano, Jorge L.& Batista, Noyde& Santiesteban, Eduardo& Lima, Mayté& González, Joaquín& García, Robin…[et al.]. Metronomic Cyclophosphamide and Methotrexate Chemotherapy Combined with 1E10 Anti-Idiotype Vaccine in Metastatic Breast Cancer. International Journal of Breast Cancer. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-492420
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492420
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر